Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19.

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Archives of Endocrinology Metabolism Pub Date : 2025-06-18 DOI:10.20945/2359-4292-2024-0113

Sara Moreira Anunciação, Renata de Oliveira Campos, Fabyan Esberard de Lima Beltrão, Déborah Araújo Morais, Wellington Sousa Tavares de, Fernando Barbosa, Jéssica Fernanda Cassemiro, Pedro Resende Ferreira Rende, Fabio Hecht, Helton Estrela Ramos

{"title":"Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19.","authors":"Sara Moreira Anunciação, Renata de Oliveira Campos, Fabyan Esberard de Lima Beltrão, Déborah Araújo Morais, Wellington Sousa Tavares de, Fernando Barbosa, Jéssica Fernanda Cassemiro, Pedro Resende Ferreira Rende, Fabio Hecht, Helton Estrela Ramos","doi":"10.20945/2359-4292-2024-0113","DOIUrl":null,"url":null,"abstract":"Objective: This study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19.Subjects and methods: A prospective study was conducted to investigate urinary selenium (Se) concentration in adult patients hospitalized with COVID-19 between June and August 2020. Urine and serum samples were collected before complications occurred, always within the first 48 hours after onset. A total of 121 patients were stratified into three tertiles based on USC: (i) USC < 25 μg/L (), (ii) USC 25-39 μg/L (), and (iii) USC > 39 μg/L (). ICP-MS was employed to measure urinary Se concentration. NTIS was defined by free triiodothyronine below 2.3 pg/L accompanied by low or normal thyroid-stimulating hormone levels.Results: NTIS was observed in a low prevalence (5.7%) and was significantly associated with patients having the lowest USC (n = 6, p = 0.008). Thyroiditis was the most prevalent thyroid complication (23.9%); however, there was no significant association with USC (p > 0.05).Conclusion: The association between low USC and NTIS was evident in this cohort.","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 3","pages":"e240113"},"PeriodicalIF":1.6000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Endocrinology Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.20945/2359-4292-2024-0113","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: This study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19.

Subjects and methods: A prospective study was conducted to investigate urinary selenium (Se) concentration in adult patients hospitalized with COVID-19 between June and August 2020. Urine and serum samples were collected before complications occurred, always within the first 48 hours after onset. A total of 121 patients were stratified into three tertiles based on USC: (i) USC < 25 μg/L (), (ii) USC 25-39 μg/L (), and (iii) USC > 39 μg/L (). ICP-MS was employed to measure urinary Se concentration. NTIS was defined by free triiodothyronine below 2.3 pg/L accompanied by low or normal thyroid-stimulating hormone levels.

Results: NTIS was observed in a low prevalence (5.7%) and was significantly associated with patients having the lowest USC (n = 6, p = 0.008). Thyroiditis was the most prevalent thyroid complication (23.9%); however, there was no significant association with USC (p > 0.05).

Conclusion: The association between low USC and NTIS was evident in this cohort.

查看原文本刊更多论文

低尿硒浓度与COVID-19住院患者非甲状腺疾病综合征相关

目的：探讨2019冠状病毒病（COVID-19）住院成人患者尿硒浓度（USC）及其与非甲状腺疾病综合征（NTIS）和炎症指标的相关性。对象与方法：采用前瞻性研究方法，对2020年6月至8月住院的COVID-19成年患者尿硒（Se）浓度进行调查。在并发症发生前采集尿液和血清样本，均在发病后48小时内采集。根据USC水平将121例患者分为3组：(i) USC < 25 μg/L (), (ii) USC 25-39 μg/L (), (iii) USC > 39 μg/L（）。采用ICP-MS法测定尿硒浓度。NTIS的定义是游离三碘甲状腺原氨酸低于2.3 pg/L，并伴有低或正常的促甲状腺激素水平。结果：NTIS的患病率较低（5.7%），且与USC最低的患者显著相关（n = 6, p = 0.008）。甲状腺炎是最常见的甲状腺并发症（23.9%）；但与USC无显著相关性（p < 0.05）。结论：低USC与NTIS之间的关联在该队列中是明显的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Archives of Endocrinology Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

2.90

自引率

5.90%

发文量

107

审稿时长

7 weeks

期刊介绍： The Archives of Endocrinology and Metabolism - AE&M – is the official journal of the Brazilian Society of Endocrinology and Metabolism - SBEM, which is affiliated with the Brazilian Medical Association. Edited since 1951, the AE&M aims at publishing articles on scientific themes in the basic translational and clinical area of Endocrinology and Metabolism. The printed version AE&M is published in 6 issues/year. The full electronic issue is open access in the SciELO - Scientific Electronic Library Online e at the AE&M site: www.aem-sbem.com. From volume 59 on, the name was changed to Archives of Endocrinology and Metabolism, and it became mandatory for manuscripts to be submitted in English for the online issue. However, for the printed issue it is still optional for the articles to be sent in English or Portuguese. The journal is published six times a year, with one issue every two months.