Gluten-Free Options for the Top 100 Pediatric Medications.

Q2 Medicine

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI:10.5863/JPPT-23-00084

Kelly L Matson, Clara L Forbes, Katelyn E Burton

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引用次数: 0

Abstract

Objective: Celiac disease and gluten sensitivities are on the rise, with a greater prevalence of the condition in children than adults. Resources to ascertain gluten content exist but can be incomplete and focus on medications for adults. The objective of this research is to determine gluten-free status of the top 100 pediatric medications dispensed.

Methods: The top 100 pediatric medications were identified by using Optum Clinformatics Data Mart database. After list creation, manufacturers and National Drug Code (NDC) for each drug were procured and used to contact manufacturers directly for gluten content information.

Results: Evaluation of 689 NDCs was completed with 50.2% of medications documented to be gluten-free. Additional categories were confirmed gluten-free but cannot confirm cross-contamination (22.6%), cannot confirm gluten-free (25.7%), and contains gluten (1.5%). Resource tables were developed from findings though information may change, based on manufacturing ingredients and processing.

Conclusions: Pediatric medications differ in gluten content, compared with medications for adults. Incomplete information exists regarding gluten content of medications, especially pediatric resources. Development of a pediatric-specific resource for gluten content of commonly dispensed medications in children and adolescents will hopefully benefit patients with celiac disease.

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前100名儿科药物的无麸质选择。

目的：乳糜泻和麸质敏感性呈上升趋势，儿童的患病率高于成人。确定谷蛋白含量的资源是存在的，但可能不完整，而且主要集中在成人的药物治疗上。本研究的目的是确定前100名儿科药物的无麸质状态。方法：利用Optum Clinformatics Data Mart数据库对排名前100位的儿科药物进行筛选。清单创建后，获取每种药物的制造商和国家药品代码（NDC），并用于直接联系制造商获取麸质含量信息。结果：689个ndc的评估完成，50.2%的药物记录为无麸质。其他类别确认无谷蛋白但无法确认交叉污染（22.6%），无法确认无谷蛋白（25.7%）和含有谷蛋白（1.5%）。资源表是根据调查结果开发的，但根据制造成分和加工过程，信息可能会发生变化。结论：与成人药物相比，儿童药物的谷蛋白含量有所不同。关于药物中麸质含量的信息不完整，尤其是儿科资源。开发儿童和青少年常用配药中麸质含量的儿科专用资源有望使乳糜泻患者受益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Pharmacology and Therapeutics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

2.40

自引率

0.00%

发文量

期刊介绍： The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.