Dietary Sugar and Sweetened Beverage Intake Increases Inflammatory Bowel Disease Risk: A Systematic Review and Meta-Analysis.

IF 5.8 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

United European Gastroenterology Journal Pub Date : 2025-06-18 DOI:10.1002/ueg2.70047

Isha Maniyar, Arpita Jajoo, Gala Godoy Brewer, Preetha Iyengar, Andrew Nguyen, Christina Fasulo, Jacob White, Alyssa Parian, Berkeley N Limketkai

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引用次数: 0

Abstract

Background and aims: The impact of dietary sugar intake on the risk of developing inflammatory bowel disease is unclear, with inconsistent findings across studies. The aim of this systematic review and meta-analysis was to clarify how sugar consumption contributes to the risk of developing inflammatory bowel disease (IBD) using the most recently available data.

Methods: A library informationist retrieved relevant articles from PubMed, EMBASE, CINAHL, Cochrane Central, Web of Science, and Scopus. Two independent reviewers screened the abstracts and full texts, yielding 45 studies for inclusion. Meta-analyses estimated odd ratios using random effect models.

Results: 11 prospective and 34 retrospective studies reported data on sugar intake and IBD risk. Pooled analysis showed that added sugar intake was associated with increased risk of Crohn's disease (OR 1.66; 95% Cl 1.21-2.29; n = 523,730; 14 studies) and ulcerative colitis (OR 1.59; 95% CI 1.25-2.02; n = 787,228; 18 studies). Similarly, soda/sweetened beverage intake was associated with increased risk of Crohn's disease (OR 1.58; 95% CI 1.18-2.12; n = 328,716; 12 studies) and ulcerative colitis (OR 1.72; 95% CI 1.23-2.391; n = 328,642; 13 studies).

Conclusions: Sugar and soda/sweetened beverage intake were associated with an increased risk of developing both Crohn's disease and ulcerative colitis. Although additional prospective investigation is warranted, current data suggest that reduction of sugar consumption might help reduce the risk of inflammatory bowel disease.

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膳食糖和含糖饮料摄入增加炎症性肠病风险：一项系统回顾和荟萃分析。

背景和目的：膳食糖摄入量对发生炎症性肠病风险的影响尚不清楚，研究结果不一致。本系统综述和荟萃分析的目的是利用最新的可用数据阐明糖摄入如何导致炎症性肠病（IBD）的风险。方法：图书馆情报员从PubMed、EMBASE、CINAHL、Cochrane Central、Web of Science和Scopus检索相关文章。两名独立审稿人筛选了摘要和全文，产生了45项研究。meta分析使用随机效应模型估计奇比。结果：11项前瞻性研究和34项回顾性研究报告了糖摄入与IBD风险的数据。综合分析显示，添加糖摄入与克罗恩病风险增加相关(OR 1.66；95% Cl 1.21-2.29；n = 523,730；14项研究)和溃疡性结肠炎(OR 1.59；95% ci 1.25-2.02；n = 787,228；18研究)。同样，苏打水/含糖饮料摄入与克罗恩病风险增加相关(OR 1.58；95% ci 1.18-2.12；n = 328716；12项研究)和溃疡性结肠炎(OR 1.72；95% ci 1.23-2.391；n = 328642；13个研究)。结论：糖和苏打水/含糖饮料的摄入与克罗恩病和溃疡性结肠炎的风险增加有关。虽然需要进一步的前瞻性研究，但目前的数据表明，减少糖的摄入可能有助于降低炎症性肠病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

United European Gastroenterology Journal GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

10.50

自引率

13.30%

发文量

147

期刊介绍： United European Gastroenterology Journal (UEG Journal) is the official Journal of the United European Gastroenterology (UEG), a professional non-profit organisation combining all the leading European societies concerned with digestive disease. UEG’s member societies represent over 22,000 specialists working across medicine, surgery, paediatrics, GI oncology and endoscopy, which makes UEG a unique platform for collaboration and the exchange of knowledge.