{"title":"[Correlation between endothelial dysfunction and sensorineural hearing loss].","authors":"V V Noskova, A N Khrabrikov","doi":"10.17116/otorino20259003113","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the characteristics of blood markers of endothelial dysfunction (ED) in patients with sensorineural hearing loss (SNHL) and in normally hearing people, to evaluate the correlation of the data obtained with SNHL degree based on the results of tonal threshold audiometry in the studied groups.</p><p><strong>Material and methods: </strong>Auditory function was studied in 94 people, including patients with chronic CHT (<i>n</i>=32), patients with acute CHT (<i>n</i>=32), and normally hearing subjects (<i>n</i>=30). Hearing assessment was carried out by recording tonal threshold audiometry, laboratory parameters were assessed by enzyme immunoassay (ELISA) and the biochemical method. Statistical processing was carried out using the Microsoft Excel 13 software package.</p><p><strong>Results: </strong>The study of biomarkers of endothelial dysfunction revealed that SNHL is characterized by impaired motor and adhesive function of vascular endothelium. Acute SNHL is more often characterized by an increase in the blood serum of the marker of vasospasm, endothelin-1 (ET-1), with the highest values (more than 0.5 pg/ml) detected in grade I and III hearing loss. On the contrary, chronic SNHL is characterized by an increase in blood serum markers of vascular endothelial adhesion disorders, namely fibrinogen and vascular endothelial adhesion molecules-1 (VCAM-1). Moreover, the highest values (more than 60 ng/ml) of the latter are found in grade II and III chronic SNHL.</p>","PeriodicalId":23575,"journal":{"name":"Vestnik otorinolaringologii","volume":"90 3","pages":"13-18"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vestnik otorinolaringologii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/otorino20259003113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To investigate the characteristics of blood markers of endothelial dysfunction (ED) in patients with sensorineural hearing loss (SNHL) and in normally hearing people, to evaluate the correlation of the data obtained with SNHL degree based on the results of tonal threshold audiometry in the studied groups.
Material and methods: Auditory function was studied in 94 people, including patients with chronic CHT (n=32), patients with acute CHT (n=32), and normally hearing subjects (n=30). Hearing assessment was carried out by recording tonal threshold audiometry, laboratory parameters were assessed by enzyme immunoassay (ELISA) and the biochemical method. Statistical processing was carried out using the Microsoft Excel 13 software package.
Results: The study of biomarkers of endothelial dysfunction revealed that SNHL is characterized by impaired motor and adhesive function of vascular endothelium. Acute SNHL is more often characterized by an increase in the blood serum of the marker of vasospasm, endothelin-1 (ET-1), with the highest values (more than 0.5 pg/ml) detected in grade I and III hearing loss. On the contrary, chronic SNHL is characterized by an increase in blood serum markers of vascular endothelial adhesion disorders, namely fibrinogen and vascular endothelial adhesion molecules-1 (VCAM-1). Moreover, the highest values (more than 60 ng/ml) of the latter are found in grade II and III chronic SNHL.
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