Relationships between Skin Structure and Skin Function of Pregnant Women and Their Infants: A Prospective Cohort Study.

IF 2.8 4区 医学 Q2 DERMATOLOGY
Doris Wilborn, Agathe Franz, Gabriela Engelhardt, Tsenka Tomova-Simitchieva, Andria Constantinou, Ruhul Amin, Kathrin Hillmann, Jan Kottner, Gavin Zhou, Ulrike Blume-Peytavi
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Abstract

In women during pregnancy and in infants during the first months after birth skin health is challenged. However, evidence about the structural and functional changes of the skin during and after pregnancy is largely lacking. The first prospective cohort study was conducted, following women from pregnancy through the postpartum period and their infants until six months of age, with skin structure and function measured at different time points. Due to the explorative character of the study, descriptive statistics were used. Over the study period, transepidermal water loss, epidermal thickness and skin roughness in women increased. Pregnancy, and postpartum period affected skin parameters such as skin roughness, epidermal thickness and transepidermal water loss, whereas stratum corneum hydration, pH, skin stiffness, and skin elasticity were not affected in women. Infants' skin barrier function matched literature values for healthy skin, with roughness and dryness decreasing through six months of age. Infant's skin barrier function characteristics matched literature values for healthy skin, with skin roughness and dryness decreasing by six months of age. Based on the findings of this observational cohort study we found no statistically significant correlation between maternal health and skin characteristics and skin characteristics of infants except for women's skin roughness and infants skin stiffness and skin elasticity and women's skin stiffness and skin elasticity and infant's skin elasticity. Therefore, based on our findings it may be justified to consider using skin care for maintaining barrier quality and function a) in pregnant women with a positive effect on skin roughness and transepidermal water loss b) in infants improving dry skin and skin roughness.

孕妇及其婴儿皮肤结构与皮肤功能的关系:一项前瞻性队列研究。
在怀孕期间的妇女和出生后最初几个月的婴儿中,皮肤健康受到挑战。然而,关于怀孕期间和怀孕后皮肤结构和功能变化的证据在很大程度上缺乏。第一项前瞻性队列研究进行了,从怀孕到产后,她们的婴儿直到六个月大,在不同的时间点测量皮肤结构和功能。由于本研究具有探索性,故采用描述性统计。在研究期间,女性经皮失水、表皮厚度和皮肤粗糙度增加。怀孕和产后会影响皮肤参数,如皮肤粗糙度、表皮厚度和经皮失水,而角质层水合、pH值、皮肤硬度和皮肤弹性对女性没有影响。婴儿的皮肤屏障功能与健康皮肤的文献值相匹配,粗糙和干燥在6个月大时减少。婴儿的皮肤屏障功能特征与健康皮肤的文献值相符,皮肤粗糙和干燥程度在6个月大时下降。根据这项观察性队列研究的结果,我们发现除了女性皮肤粗糙度和婴儿皮肤硬度和皮肤弹性以及女性皮肤硬度和皮肤弹性和婴儿皮肤弹性外,母亲健康与皮肤特征和婴儿皮肤特征之间没有统计学意义上的相关性。因此,根据我们的研究结果,考虑使用皮肤护理来维持屏障的质量和功能可能是合理的:a)在孕妇中对皮肤粗糙度和经皮失水有积极影响;b)在婴儿中改善皮肤干燥和皮肤粗糙度。
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来源期刊
Skin Pharmacology and Physiology
Skin Pharmacology and Physiology 医学-皮肤病学
CiteScore
5.20
自引率
7.40%
发文量
23
审稿时长
>12 weeks
期刊介绍: In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.
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