Enterovirus A-71 Associated Parainfectious Movement Disorders in Children.

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY

Movement Disorders Clinical Practice Pub Date : 2025-06-18 DOI:10.1002/mdc3.70182

Suus A M van Noort, Jan Willem J Elting, Thomas Foiadelli, Petra J J S Peters, Joost Nicolai, Marina A J Tijssen, Jelte Helfferich

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引用次数: 0

Abstract

Background: Pediatric movement disorders can be challenging to characterize, given the phenotypic complexity and broad differential diagnosis. While genetic tests are often part of the diagnostic work-up, it is important to consider acquired causes, which may require specific investigations. Enterovirus A-71 (EV-A71) associated rhombencephalitis frequently presents with movement disorders. We aim to improve the recognition of these phenotypes.

Cases: We describe four patients (aged 21 months-12 years) presenting with movement disorders and a confirmed EV-A71 infection. All patients had myoclonus, one suffered from ataxia. Both focal arm flexion myoclonus and generalized myoclonus were observed. Polymyography demonstrated a subcortical origin. The movement disorders subsided with infection improvement.

Conclusions: Recognition of EV-A71 parainfectious movement disorders in childhood enables clinicians to obtain appropriate, cost-effective diagnostics. When an EV-A71 infection is suspected PCR-diagnostics in stool and nasopharynx material is required. Neuroimaging and polymyography can support the diagnosis.

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儿童肠道病毒A-71相关的副感染性运动障碍

背景：鉴于儿童运动障碍的表型复杂性和广泛的鉴别诊断，其特征可能具有挑战性。虽然基因测试通常是诊断检查的一部分，但重要的是要考虑获得性原因，这可能需要具体的调查。肠病毒A-71 （EV-A71）相关的菱形脑炎通常表现为运动障碍。我们的目标是提高对这些表型的认识。病例：我们描述了4例患者（年龄21个月至12岁）表现为运动障碍和确诊的EV-A71感染。所有患者均有肌阵挛，1例有共济失调。局灶性手臂屈曲性肌阵挛和全身性肌阵挛均可观察到。多肌图显示皮层下起源。运动障碍随着感染的改善而消退。结论：识别EV-A71儿童副感染性运动障碍使临床医生能够获得适当的、具有成本效益的诊断。当怀疑EV-A71感染时，需要对粪便和鼻咽材料进行pcr诊断。神经影像学和多肌图可支持诊断。

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)