Insulin-Like Growth Factor Binding Protein, Acid-Labile Subunit Serum Level During the Acute and Convalescent Stage of SARS-CoV-2 Infection Depicted in a Longitudinal Study of 72 Patients During the First Wave of Pandemic.

IF 2.4 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Journal of Multidisciplinary Healthcare Pub Date : 2025-06-14 eCollection Date: 2025-01-01 DOI:10.2147/JMDH.S515244
Hossam Gad, Mohamed A Mahmoud, Mohamed Antar, Ahmed Sayed Ahmed, Krzysztof Laudanski
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引用次数: 0

Abstract

Purpose: Recent discoveries have pointed to the role of IGFALS immunological response to viral challenges, potentially leading to the emergence of a cytokine storm. Here, we investigate if serum IGFALS during the acute response to SARS-CoV-2 will not be likely to accompany immune response during acute phase and convalescence.

Patients and methods: We recruited patients hospitalized with PCR-confirmed SARS-CoV-2 infection in 2020 and have blood collected after securing consent (tadm), at 48 hours (t48hrs), 7 days (t7d), and after discharge from hospital (tlong). IGFALS and IGF-1 in serum were measured to assess dynamics of the illness and compared against non-specific inflammatory (C-reactive protein, IL-6) markers. Serum titers of IgG against proteins S and N assessed specific viral responses. Serum HMGB-1 was measured to assess level of necrosis. Demographic and clinical data were collected using electronic health records (EHR). Survival was determined at six months from admission.

Results: No difference between serum IGFALS and IGF-1 levels was seen across the studied time points. IGFALSadm showed significant positive correlations with IGFALS48hrs (r2 =0.18; p<0.001), IGFALS7d (r2=0.19; p=0.004), and IGFALSlong (r2 = 0.23; p=0.045). IGFALS correlated negatively with IGF-1 but positively with growth hormone. IGFALSadm showed significant inverse correlations with serum levels of HMGB1adm (r2=0.26; p = <0.001) and t48hr (r2 = 0.27; p<0.001). A significant correlation in the case of IGFALS48hrs and CRP48hrs (r2 = 0.09, p = 0.021), IGFALSlong and CRPlong (r2 = 0.271, p=0.039) was seen. Similar correlations were seen at 48 hours of sampling time for IL-6 (r2 = 0.14, p=0.006). In terms of specific antiviral response, we observed that serum IGFALSadm demonstrated correlation levels of serum IgGadm (r2 = 0.09, p=0.024). A positive correlation was found between length of stay in hospital or ICU and serum IGFALS48hrs.

Conclusion: Though IGFALS serum levels did not change significantly during SARS-CoV-2 infection, we observed correlations with markers of tissue destruction, C-reactive protein, IL-6, and length of hospital stay.

第一波大流行期间72例SARS-CoV-2感染急性和恢复期患者胰岛素样生长因子结合蛋白、酸不稳定亚基血清水平的纵向研究
目的:最近的发现指出了IGFALS对病毒挑战的免疫反应的作用,可能导致细胞因子风暴的出现。在这里,我们研究急性SARS-CoV-2反应期间血清IGFALS是否不可能伴随急性期和恢复期的免疫反应。患者和方法:我们招募了2020年因pcr确诊的SARS-CoV-2感染住院的患者,并在征得同意后(tadm)、48小时(t48hrs)、7天(t7d)和出院后(tlong)采血。测量血清IGFALS和IGF-1以评估疾病的动态,并与非特异性炎症(c反应蛋白,IL-6)标志物进行比较。血清中针对S蛋白和N蛋白的IgG滴度评估特异性病毒反应。测定血清HMGB-1以评估坏死程度。使用电子健康记录(EHR)收集人口统计和临床数据。入院后6个月确定生存期。结果:血清IGFALS和IGF-1水平在研究时间点之间没有差异。IGFALSadm与IGFALS48hrs呈显著正相关(r2 =0.18;p7d (r2 = 0.19;p=0.004), IGFALSlong (r2 = 0.23;p = 0.045)。IGFALS与IGF-1呈负相关,与生长激素呈正相关。IGFALSadm与血清HMGB1adm水平呈显著负相关(r2=0.26;P = 48小时(r2 = 0.27;可见p48hrs和CRP48hrs (r2 = 0.09, p= 0.021), IGFALSlong和CRPlong (r2 = 0.271, p=0.039)。在采样时间48小时时,IL-6也出现了类似的相关性(r2 = 0.14, p=0.006)。在特异性抗病毒反应方面,我们观察到血清IGFALSadm与血清IgGadm具有相关性(r2 = 0.09, p=0.024)。住院或ICU住院时间与血清igfals48小时呈正相关。结论:虽然IGFALS血清水平在SARS-CoV-2感染期间没有显著变化,但我们观察到与组织破坏、c反应蛋白、IL-6和住院时间相关的标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Multidisciplinary Healthcare
Journal of Multidisciplinary Healthcare Nursing-General Nursing
CiteScore
4.60
自引率
3.00%
发文量
287
审稿时长
16 weeks
期刊介绍: The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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