Effective Dosage of Ciprofol for the Induction of General Anesthesia Across Diverse Age Groups in Adults: A Single-Center, Prospective, Non-Randomized Sequential Trial.

IF 2.5 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Pain Research Pub Date : 2025-06-14 eCollection Date: 2025-01-01 DOI:10.2147/JPR.S496223

Lizhen Deng, Chunyuan Zhang, Meiyun Tan, Wei Zeng, Guozhan Luo, Ping Li

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引用次数: 0

Abstract

Purpose: A new Chinese-developed intravenous anesthetic called ciprofol enhances propofol's effectiveness against GABAA receptors by adding cyclopropyl. This study aims to determine the optimal dosage of ciprofol for inducing general anesthesia in adult patients of different ages and its correlation with Narcotrend index (NTI).

Patients and methods: 105 patients were stratified into three age groups: 18-40 (Group A), 41-65 (Group B), and 66-85 (Group C) years. Initial doses of 0.4 mg/kg (Groups A and B) and 0.3 mg/kg (Group C) ciprofol tosilate were administered, adjusted by 0.05 mg/kg based on sedation efficacy. The Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale and Dixon up-and-down method were used to calculate ED50, ED95, and NTI50.

Results: Effective dosages were: youth (ED50=0.526 mg/kg, ED95=0.610 mg/kg), middle-aged (ED50=0.366 mg/kg, ED95=0.450 mg/kg), and elderly (ED50=0.324 mg/kg, ED95=0.408 mg/kg). NTI50 were 38.068 (33.496-44.188), 44.963 (39.311-52.270), and 47.214 (39.792-57.420) for the three groups, respectively.

Conclusion: Ciprofol is safe and effective for anesthesia induction across age groups, with lower doses required for elderly patients. NTI reduction was dose-dependent and slower in elderly patients.

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环丙酚诱导不同年龄组成人全身麻醉的有效剂量：一项单中心、前瞻性、非随机序贯试验

目的：一种新型静脉麻醉剂环丙酚通过添加环丙基来增强异丙酚对GABAA受体的有效性。本研究旨在确定不同年龄成人患者诱导全身麻醉的最佳环丙酚用量及其与麻醉趋势指数（NTI）的相关性。患者与方法：105例患者分为3个年龄组：18-40岁（A组）、41-65岁（B组）和66-85岁（C组）。初始剂量分别为0.4 mg/kg （A组和B组）和0.3 mg/kg （C组），根据镇静效果调整为0.05 mg/kg。采用MOAA/S （Modified Observer’S Assessment of Alertness/Sedation）量表和Dixon上下法计算ED50、ED95和NTI50。结果：有效剂量分别为青年（ED50=0.526 mg/kg, ED95=0.610 mg/kg）、中年（ED50=0.366 mg/kg, ED95=0.450 mg/kg）、老年（ED50=0.324 mg/kg, ED95=0.408 mg/kg）。三组NTI50分别为38.068（33.496 ~ 44.188）、44.963（39.311 ~ 52.270）、47.214（39.792 ~ 57.420）。结论：环丙酚用于各年龄组麻醉诱导安全有效，老年患者所需剂量较低。老年患者的NTI降低呈剂量依赖性，且速度较慢。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pain Research CLINICAL NEUROLOGY-

CiteScore

4.50

自引率

3.70%

发文量

411

审稿时长

16 weeks

期刊介绍： Journal of Pain Research is an international, peer-reviewed, open access journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication. Additionally, the journal now welcomes the submission of pain-policy-related editorials and commentaries, particularly in regard to ethical, regulatory, forensic, and other legal issues in pain medicine, and to the education of pain practitioners and researchers.