Ethnopharmacological Profile, Phytochemistry and Therapeutic Potential of Aegle marmelos L. for the Treatment of Neurological Disorders.

IF 2.4 Q3 NUTRITION & DIETETICS
Journal of Nutrition and Metabolism Pub Date : 2025-06-11 eCollection Date: 2025-01-01 DOI:10.1155/jnme/2275526
Ashwani Sharma, Dalapatghi Gugulothu, Tarun Virmani, Anjali Sharma, Girish Kumar, Kuldeep Singh, Divya Jain, Md Shimul Bhuia, Raihan Chowdhury, Nowreen Tabassum Ahammed, Muhammad Torequl Islam
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Abstract

Aegle marmelos (L.) Corrêa, commonly known as the bael fruit tree, is a member of the Rutaceae family and holds significance in Ayurvedic herbal medicine due to its myriad therapeutic properties. This paper seeks to delve into the diverse benefits offered by the bael fruit tree, exploring various plant parts, including leaves, fruit, bark, and seeds, all of which contain bioactive compounds with therapeutic potential. The bael fruit, with its diverse phytochemical profile, exhibits potential health benefits ranging from radioprotection and antibacterial properties to antioxidant and hepatoprotective effects. Additionally, this review highlights the limited preclinical studies on AMs' efficacy in treating neurological disorders, emphasizing the need for more clinical trials to validate its potency and safety. Specifically, the effects and mechanisms of AM extract in addressing Alzheimer's disease, anxiety, depression, epilepsy and Parkinson's disease are explored. In conclusion, AM emerges as a plant of considerable nutritional and pharmacological value, with the potential to contribute significantly to the treatment of neurological disorders. Despite its promising attributes, the limited preclinical studies necessitate further clinical trials to confirm its efficacy. This review consolidates relevant studies, offering insights into AMs' ethnobotany, chemical constituents, pharmacological properties and potential application in neurological disorders. The comprehensive examination underscores the need for continued research to unlock the full therapeutic potential of this versatile plant.

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柑桔的民族药理学、植物化学及治疗神经系统疾病的潜力。
安吉尔甜瓜(L.)Corrêa,通常被称为bael果树,是芦花科的一员,由于其无数的治疗特性,在阿育吠陀草药中具有重要意义。本文旨在深入研究bael果树提供的各种益处,探索各种植物部分,包括叶子,果实,树皮和种子,所有这些都含有具有治疗潜力的生物活性化合物。bael果实具有多种植物化学成分,显示出潜在的健康益处,从防辐射和抗菌特性到抗氧化和肝脏保护作用。此外,本综述强调了AMs治疗神经系统疾病的临床前研究有限,强调需要更多的临床试验来验证其效力和安全性。具体而言,探讨AM提取物在治疗阿尔茨海默病、焦虑、抑郁、癫痫和帕金森病中的作用和机制。综上所述,AM是一种具有相当营养和药理价值的植物,有可能对神经系统疾病的治疗做出重大贡献。尽管其有希望的属性,有限的临床前研究需要进一步的临床试验来证实其疗效。本文综述了相关研究成果,对AMs的民族植物学、化学成分、药理特性及其在神经系统疾病中的潜在应用提供了新的见解。综合检查强调需要继续研究,以释放这种多功能植物的全部治疗潜力。
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来源期刊
Journal of Nutrition and Metabolism
Journal of Nutrition and Metabolism NUTRITION & DIETETICS-
CiteScore
5.40
自引率
0.00%
发文量
49
审稿时长
17 weeks
期刊介绍: Journal of Nutrition and Metabolism is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering the broad and multidisciplinary field of human nutrition and metabolism. The journal welcomes submissions on studies related to obesity, diabetes, metabolic syndrome, molecular and cellular biology of nutrients, foods and dietary supplements, as well as macro- and micronutrients including vitamins and minerals.
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