Interaction Between Group 3 Innate Lymphoid Cells, Microbiota, and Intestinal Diseases: Mechanisms and Therapeutic Potential.

IF 4.7 3区 医学 Q2 IMMUNOLOGY
Lijie Hao, Yi Ge, Zhuo Chen, Duo Yuan, Xiaoyan Zhang, Huihong Zhai, Ziyu Liu
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引用次数: 0

Abstract

Background: The incidence of intestinal diseases is increasing every year, placing a heavy burden on the world's health and economy. The interaction of immune, microbial, and environmental factors leading to chronic inflammation and immune dysfunction has gradually become a focus of research on the pathogenesis of intestinal diseases. Among them, type 3 innate lymphoid cells (ILC3s) have attracted much attention due to their unique features.

Summary: This paper has been carefully reviewed to provide a comprehensive overview of the roles of ILC3s in maintaining the homeostasis of intestinal flora. Initially, the effects of various intestinal microbiota, including bacteria, fungi, viruses, and pathogenic bacteria, on the function of ILC3s were introduced in detail. Subsequently, summarize how ILC3s imbalance disrupts the intestinal barrier and leads to digestive diseases, including infectious diseases, colorectal cancer (CRC), inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS).

Key messages: By reviewing the role of ILC3s in maintaining the homeostasis of the intestinal flora and the current research status of ILC3s imbalance disrupting the intestinal barrier and leading to digestive tract diseases, this review provides potential immunotherapy targets for the future and offers a basis for the construction of future animal models and the conduct of clinical trials.

第3组先天淋巴样细胞、微生物群与肠道疾病的相互作用:机制和治疗潜力。
背景:肠道疾病的发病率每年都在增加,给世界卫生和经济带来了沉重的负担。免疫、微生物和环境因素的相互作用导致慢性炎症和免疫功能障碍逐渐成为肠道疾病发病机制的研究热点。其中,3型先天淋巴样细胞(type 3 innate lymphoid cells, ILC3s)因其独特的特性而备受关注。摘要:本文对ILC3s在维持肠道菌群稳态中的作用进行了综述。首先,详细介绍了各种肠道微生物群,包括细菌、真菌、病毒和致病菌对ILC3s功能的影响。随后,总结ILC3s失衡如何破坏肠道屏障,导致消化道疾病,包括感染性疾病、结直肠癌(CRC)、炎症性肠病(IBD)和肠易激综合征(IBS)。关键信息:本文通过综述ILC3s在维持肠道菌群稳态中的作用,以及ILC3s失衡破坏肠道屏障导致消化道疾病的研究现状,为未来潜在的免疫治疗靶点,为未来动物模型的构建和临床试验的开展提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Innate Immunity
Journal of Innate Immunity 医学-免疫学
CiteScore
10.50
自引率
1.90%
发文量
35
审稿时长
7.5 months
期刊介绍: The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.
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