Role of Macrophage Polarization in Chronic Rhinosinusitis Based on the Yin-Yang Theory: A Review.

IF 4.2 2区医学 Q2 IMMUNOLOGY

Journal of Inflammation Research Pub Date : 2025-06-13 eCollection Date: 2025-01-01 DOI:10.2147/JIR.S514060

Fei Wang, Ye Xiong, Yaxian Zhu, Xiaoqian Yang, Kai Liu, Zhenhua Zhu

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引用次数: 0

Abstract

Background: Chronic rhinosinusitis (CRS) is a prevalent otolaryngologic condition that markedly impacts patients' quality of life; however its pathogenesis is intricate and the clinical efficacy of known treatments remains limited.

Methods: In recent years, there has been a growing focus on the role of immune function in the pathogenesis of CRS. Recent studies have revealed a correlation between macrophage polarization and CRS development. Macrophage polarization denotes distinct phenotypes of macrophages in diverse microenvironments, with the M1 and M2 phenotypes sharing similarities with the Yin-Yang concept of traditional Chinese medicine, encompassing mutual support and utilization, a balance between growth and elimination, and self-healing and equilibrium.

Results: This study briefly reviews the latest research on traditional Chinese medicine compound prescriptions and the regulation of macrophage polarization by traditional Chinese medicine monomers, aligned with the main treatment principles of CRS, with the aim of offering novel directions and strategies for the clinical management of this condition.

Conclusion: This study investigated the role of macrophage polarization in CRS from the perspective of the Yin-Yang Theory of traditional Chinese medicine.

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基于阴阳理论的巨噬细胞极化在慢性鼻窦炎中的作用综述。

背景：慢性鼻窦炎（CRS）是一种常见的耳鼻喉疾病，显著影响患者的生活质量；然而，其发病机制复杂，已知治疗方法的临床疗效仍然有限。方法：近年来，免疫功能在CRS发病机制中的作用越来越受到关注。近年来的研究揭示了巨噬细胞极化与CRS发生的相关性。巨噬细胞极化是指巨噬细胞在不同微环境下表现出不同的表型，其中M1和M2表型与中医阴阳概念有相似之处，包括相互支持和利用，生长和消除之间的平衡，自我修复和平衡。结果：本研究结合CRS的主要治疗原则，简要综述了中药复方方剂及中药单体调控巨噬细胞极化的最新研究进展，旨在为CRS的临床治疗提供新的方向和策略。结论：本研究从中医阴阳理论角度探讨巨噬细胞极化在CRS中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inflammation Research Immunology and Microbiology-Immunology

CiteScore

6.10

自引率

2.20%

发文量

658

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.