Depression and anxiety in adolescents with cystic fibrosis in Brazil: prevalence, stability over time, and relationship with treatment adherence.

IF 2.9 4区医学 Q2 RESPIRATORY SYSTEM

Jornal Brasileiro De Pneumologia Pub Date : 2025-06-13 eCollection Date: 2025-01-01 DOI:10.36416/1806-3756/e20240416

Tatiana Rozov, Marcos Tadeu Nolasco da Silva, Maria Ângela Gonçalves Oliveira Ribeiro, Neiva Damaceno, Maria Angelica Pinheiro Santos Santana, Paulo Jose Cauduro Marostica, Roberta de Cássia Nunes Cruz Melotti, Valeria de Carvalho Martins, Carlos Antônio Riedi, Edna Lucia Santos de Souza, Norberto Ludwig Neto, Rodrigo Abensur Athanazio, Francyelly Wisnievski Yamamoto, Lusmaia Damaceno Camargo Costa, Sonia Mayumi Chiba, Izabela Sad, José Dirceu Ribeiro, Alexandra L Quittner

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引用次数: 0

Abstract

Objective: Depression and anxiety have been documented in people with cystic fibrosis (CF), jeopardizing treatment adherence. To date, no studies have assessed the prevalence of psychosocial issues in adolescents with CF in Brazil. We sought to assess the prevalence of depression and anxiety in adolescents with CF in Brazil, as well as the impact of depression and anxiety on treatment adherence.

Methods: This was a multicenter, prospective, observational, longitudinal study conducted between 2017 and 2019 at 14 CF referral centers in Brazil. We used standardized tools such as the nine-item Patient Health Questionnaire (for depression), the seven-item Generalized Anxiety Disorder scale (for anxiety), and the eight-item Morisky Medication Adherence Scale (for treatment adherence) in order to collect data on 218 CF patients at two different time points.

Results: The prevalence of depression was 19.1% at time point 1 and 15.4% at time point 2. The prevalence of anxiety was 19.1% at time point 1 and 18.0% at time point 2. Depression and anxiety were significantly higher in female patients and lower in those who underwent home physiotherapy or had psychological support. Significant correlations were found between depression and anxiety at both time points, the associations being strongest at time point 1 (r = 0.68; p < 0.001). Most (66.7%) of the study participants reported low adherence to treatment, and the remainder reported either average adherence (in 28%) or high adherence (in 5.3%). Depression and anxiety showed inverse correlations with treatment adherence.

Conclusions: The prevalence of depression and anxiety in adolescents with CF in Brazil appears to be similar to that reported in other countries, being higher in females and lower in those undergoing home physiotherapy or receiving psychological care. Depression and anxiety appear to correlate with lower treatment adherence. Treating psychosocial issues may effectively improve rates of treatment adherence in adolescents with CF.

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巴西囊性纤维化青少年的抑郁和焦虑：患病率、长期稳定性以及与治疗依从性的关系

目的：囊性纤维化（CF）患者存在抑郁和焦虑，危及治疗依从性。迄今为止，还没有研究评估巴西青少年CF患者的社会心理问题的流行程度。我们试图评估巴西CF青少年中抑郁和焦虑的患病率，以及抑郁和焦虑对治疗依从性的影响。方法：这是一项多中心、前瞻性、观察性、纵向研究，于2017年至2019年在巴西的14个CF转诊中心进行。我们使用标准化工具，如9项患者健康问卷（抑郁症）、7项广泛性焦虑障碍量表（焦虑症）和8项Morisky药物依从性量表（治疗依从性），以收集218名CF患者在两个不同时间点的数据。结果：抑郁患病率在时间点1为19.1%，时间点2为15.4%。焦虑的患病率在时间点1为19.1%，在时间点2为18.0%。女性患者的抑郁和焦虑明显较高，而接受家庭物理治疗或心理支持的患者则较低。抑郁与焦虑在两个时间点均存在显著相关，在时间点1相关性最强(r = 0.68；P < 0.001)。大多数（66.7%）的研究参与者报告治疗依从性低，其余的报告平均依从性（28%）或高依从性（5.3%）。抑郁和焦虑与治疗依从性呈负相关。结论：巴西CF青少年抑郁和焦虑的患病率似乎与其他国家的报告相似，女性较高，而接受家庭物理治疗或心理护理的青少年较低。抑郁和焦虑似乎与较低的治疗依从性相关。治疗心理社会问题可以有效提高CF青少年患者的治疗依从性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal Brasileiro De Pneumologia RESPIRATORY SYSTEM-

CiteScore

3.50

自引率

14.80%

发文量

118

审稿时长

20 weeks

期刊介绍： The Brazilian Journal of Pulmonology publishes scientific articles that contribute to the improvement of knowledge in the field of the lung diseases and related areas.