Clinicopathologic features of 89 patients with lacrimal gland prolapse.

IF 1.9 4区医学 Q2 OPHTHALMOLOGY

International journal of ophthalmology Pub Date : 2025-06-18 eCollection Date: 2025-01-01 DOI:10.18240/ijo.2025.06.06

Yu-Yao Qu, Le Dong, Ya-Guang Hu, Ning Gao, Jing-Ming Li, Qiao-Chu Cheng, Shan Gao, Ting Wei, Jian-Min Ma, Wan-Hu Zhang

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Abstract

Aim: To analyze the clinical and pathological features of 89 patients presenting as lacrimal gland prolapse (LGP).

Methods: This retrospective study included 89 patients presenting as LGP. Magnetic resonance imaging (MRI) scan was performed for all patients. Pathology and immunohistochemical staining of prolapsed tissue were performed during the surgery. The histopathological subtype was obtained, and the related clinical manifestations of different subtype were marked.

Results: Among the 89 patients involved, the histopathological subtype includes dacryoadenitis (43%; n=38), focal lymphocytes infiltration (20%; n=18), immunoglobulin G4 (IgG4)-related lacrimal gland inflammatory disease (15%; n=13), lacrimal gland (13%; n=12), and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (9%; n=8). As for manifestations of different subtypes, eyelid swelling was found the most frequent of lymphocytes infiltration (44%, n=8), and palpable lacrimal gland mass of dacryoadenitis (55%, n=21). All the IgG4-related lacrimal gland inflammatory disease (100%, n=13) and most dacryoadenitis (97%, n=37) presented as bilateral.

Conclusion: LGP has the histopathological subtype most commonly as inflammation, followed by structural and lymphoproliferative changes. Most of patients present as eyelid swelling. Clinical manifestations can be significant to differentiate the diagnosis.

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89例泪腺脱垂的临床病理特征分析。

目的：分析89例泪腺脱垂（LGP）患者的临床及病理特点。方法：回顾性研究89例LGP患者。所有患者均行磁共振成像（MRI）扫描。术中对脱垂组织进行病理及免疫组化染色。获得组织病理学亚型，并标记不同亚型的相关临床表现。结果：89例患者中，组织病理学亚型包括泪腺炎（43%）；N =38)，局灶性淋巴细胞浸润(20%；n=18)，免疫球蛋白G4 （IgG4）相关的泪腺炎性疾病(15%；N =13)，泪腺(13%；结外边缘区粘膜相关淋巴组织b细胞淋巴瘤(9%；n = 8)。在不同亚型的表现中，眼睑肿胀以淋巴细胞浸润最常见（44%,n=8），泪腺炎可触及的泪腺肿块最常见（55%,n=21）。所有igg4相关的泪腺炎症性疾病（100%,n=13）和大多数泪腺炎（97%,n=37）表现为双侧。结论：LGP的组织病理学亚型以炎症最常见，其次为结构和淋巴细胞增生性改变。多数患者表现为眼睑肿胀。临床表现对鉴别诊断具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of ophthalmology Medicine-Ophthalmology

CiteScore

2.50

自引率

7.10%

发文量

3141

审稿时长

4-8 weeks

期刊介绍： · International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online). This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed, PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166. IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO); Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President, Chinese Academy of Engineering. International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of AAO/PAAO) et al. Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society). Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press). Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics). Associate Editors-in-Chief include: Prof. Ning-Li Wang (President Elect of APAO); Prof. Ke Yao (President of Chinese Ophthalmological Society) ; Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ; Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA); Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society); Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA); Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA). IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles, both basic and clinical papers. Instruction is Welcome Contribution is Welcome Citation is Welcome Cooperation organization International Council of Ophthalmology(ICO), PubMed, PMC, American Academy of Ophthalmology, Asia-Pacific, Thomson Reuters, The Charlesworth Group, Crossref,Scopus,Publons, DOAJ etc.