{"title":"Hematological inflammation biomarkers in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.","authors":"Alper Can Yilmaz, Hayati Yilmaz","doi":"10.18240/ijo.2025.06.10","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To evaluate complete blood count and biochemical parameters in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG) and compare the results with healthy controls.</p><p><strong>Methods: </strong>Forty-four patients with PEXS, 61 patients with PEXG, and 55 healthy subjects were enrolled in this retrospective study. All systemic and especially pseudoexfoliation-related ophthalmic examination findings of the participants were evaluated. Complete blood count, glucose, creatinine, and serum lipid values were obtained. In line with these data, monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, monocyte-to-high density lipoprotein (HDL) ratio (MHR), and mean platelet volume-to-platelet count ratio were obtained and comparison were made among groups.</p><p><strong>Results: </strong>Diabetes mellitus and hypertension were significantly more common in the PEXS and PEXG groups than in the control group (<i>P</i>=0.021, <i>P</i>=0.016, respectively). In the analysis of complete blood count parameters, NLR and MHR values were statistically significantly higher in PEXS and PEXG compared to the control group (<i>P</i>=0.037, <i>P</i>=0.025, respectively). In addition, glucose, low-density lipoprotein, and triglyceride values were significantly higher in the PEXS and PEXG groups compared to the control group (<i>P</i><0.001, <i>P</i>=0.035, <i>P</i><0.001, respectively), and HDL value was significantly lower (<i>P</i>=0.031).</p><p><strong>Conclusion: </strong>The hematological inflammation biomarkers we evaluated in our study provide evidence that systemic inflammation and oxidative stress processes play an important role in the pathogenesis of PEXS and PEXG.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 6","pages":"1042-1052"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120449/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18240/ijo.2025.06.10","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: To evaluate complete blood count and biochemical parameters in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG) and compare the results with healthy controls.
Methods: Forty-four patients with PEXS, 61 patients with PEXG, and 55 healthy subjects were enrolled in this retrospective study. All systemic and especially pseudoexfoliation-related ophthalmic examination findings of the participants were evaluated. Complete blood count, glucose, creatinine, and serum lipid values were obtained. In line with these data, monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, monocyte-to-high density lipoprotein (HDL) ratio (MHR), and mean platelet volume-to-platelet count ratio were obtained and comparison were made among groups.
Results: Diabetes mellitus and hypertension were significantly more common in the PEXS and PEXG groups than in the control group (P=0.021, P=0.016, respectively). In the analysis of complete blood count parameters, NLR and MHR values were statistically significantly higher in PEXS and PEXG compared to the control group (P=0.037, P=0.025, respectively). In addition, glucose, low-density lipoprotein, and triglyceride values were significantly higher in the PEXS and PEXG groups compared to the control group (P<0.001, P=0.035, P<0.001, respectively), and HDL value was significantly lower (P=0.031).
Conclusion: The hematological inflammation biomarkers we evaluated in our study provide evidence that systemic inflammation and oxidative stress processes play an important role in the pathogenesis of PEXS and PEXG.
期刊介绍：
· International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication
and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online).
This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from
WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed,
PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166.
IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific
Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO);
Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President,
Chinese Academy of Engineering.
International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of
blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of
AAO/PAAO) et al.
Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of
Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and
Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society).
Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press).
Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and
Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics).
Associate Editors-in-Chief include:
Prof. Ning-Li Wang (President Elect of APAO);
Prof. Ke Yao (President of Chinese Ophthalmological Society) ;
Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ;
Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA);
Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society);
Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA);
Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA).
IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles,
both basic and clinical papers.
Instruction is Welcome Contribution is Welcome Citation is Welcome
Cooperation organization
International Council of Ophthalmology(ICO), PubMed, PMC, American Academy of Ophthalmology, Asia-Pacific, Thomson Reuters, The Charlesworth Group, Crossref,Scopus,Publons, DOAJ etc.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
