Potential interactions between STING pathway and the complement system in immune regulation.

IF 3.9 3区医学 Q2 IMMUNOLOGY

Expert Review of Clinical Immunology Pub Date : 2025-07-01 Epub Date: 2025-06-24 DOI:10.1080/1744666X.2025.2522264

BingXiao Zhang, Yu Chen, ChenGuang Wang, WenFeng Gou, Yiliang Li, Wenbin Hou, FuJun Zhou

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引用次数: 0

Abstract

Introduction: The innate immune system's complement system and cGAS-STING pathway play crucial roles in pathogen defense and immune response modulation. Complement's role in cancer is multifaceted, affecting myeloid cells and T cell activities, while intracellular complement (complosome) participates in cellular processes like metabolism and autophagy. STING's activation influences tumor dynamics through NF-κB pathway interactions, enhancing or suppressing tumor responses. The interplay between complement and cGAS-STING pathways suggests potential regulatory crosstalk affecting immune responses, warranting further investigation.

Areas covered: We review the functions of the complement system and the cGAS-STING pathway in pathogen clearance and tumor development. The focus is on exploring the intricate interplay between these pathways and discussing its implications for disease pathogenesis ;(PubMed: 1983-2024).

Expert opinion: Such insights into these pathways could guide therapeutic strategies targeting immune modulation in oncology and autoimmune disorders, emphasizing the need to understand their complex roles in health and disease.

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STING通路与补体系统在免疫调节中的潜在相互作用。

先天免疫系统的补体系统和cGAS-STING通路在病原体防御和免疫应答调节中起着重要作用。补体在癌症中的作用是多方面的，影响髓细胞和T细胞的活性，而细胞内补体（复合体）参与细胞代谢和自噬等过程。STING的激活通过NF-κB通路相互作用影响肿瘤动力学，增强或抑制肿瘤反应。补体和cGAS-STING通路之间的相互作用提示潜在的调节串扰影响免疫应答，值得进一步研究。涉及领域：我们综述了补体系统和cGAS-STING通路在病原体清除和肿瘤发展中的功能。重点是探索这些途径之间复杂的相互作用，并讨论其对疾病发病机制的影响；（PubMed: 1983-2024）专家意见：对这些途径的深入了解可以指导针对肿瘤和自身免疫性疾病的免疫调节的治疗策略，强调有必要了解它们在健康和疾病中的复杂作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Clinical Immunology IMMUNOLOGY-

CiteScore

7.60

自引率

2.30%

发文量

221

审稿时长

6-12 weeks

期刊介绍： Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.