First-generation versus next-generation epigenetic aging clocks: Differences in performance and utility.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Adiv A Johnson, Maxim N Shokhirev
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引用次数: 0

Abstract

Aging biomarkers that predict age given methylomic data are referred to as epigenetic aging clocks. While the earliest, first-generation clocks were exclusively trained to predict chronological age, more recent next-generation models have been explicitly trained to associate with health, lifestyle, and/or age-related outcomes. Although these next-generation models have been trained using distinct approaches and techniques, existing evidence indicates that they associate with a greater number of health and disease signals than first-generation clocks. Moreover, they are often more predictive of age-related outcomes and appear more responsive to interventions. In this work, we provide definitions for first- versus next-generation clocks and discuss the potential merits of further dividing next-generation clocks into sub-categories. In addition, we summarize existing next-generation epigenetic aging clocks, including how they were trained and how they can be accessed. Given the relative value of interventional data over observational data, we comprehensively tabulate existing literature documenting the ability of an intervention to influence at least one epigenetic aging clock. While we acknowledge that the decision to a use a specific clock is ultimately dependent on the research application and goal, current evidence suggests that next-generation models should be generally prioritized for health-oriented association and interventional studies.

第一代与下一代表观遗传衰老时钟:性能和效用的差异。
根据甲基组学数据预测年龄的衰老生物标志物被称为表观遗传衰老时钟。虽然最早的第一代时钟专门用于预测实足年龄,但最近的下一代模型已被明确训练与健康、生活方式和/或与年龄相关的结果相关联。虽然这些新一代的模型是使用不同的方法和技术进行训练的,但现有证据表明,与第一代时钟相比,它们与更多的健康和疾病信号相关。此外,它们往往更能预测与年龄相关的结果,对干预措施的反应也更灵敏。在这项工作中,我们提供了第一代时钟与下一代时钟的定义,并讨论了进一步将下一代时钟划分为子类别的潜在优点。此外,我们总结了现有的下一代表观遗传衰老时钟,包括它们是如何训练和如何访问的。考虑到干预数据相对于观察数据的相对价值,我们综合整理了现有文献,记录了干预影响至少一个表观遗传衰老时钟的能力。虽然我们承认使用特定时钟的决定最终取决于研究应用和目标,但目前的证据表明,下一代模型通常应优先用于面向健康的关联和介入性研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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