Real-World Health and Economic Effects of a Large-Scale Outpatient Screening and Continuing Care Programme for Early Detection and Care of Microvascular Complications in Patients with Type 2 Diabetes Implemented in Routine Care Across Germany: A Quasi-Experimental Study Using Health Insurance Claims Data.

IF 3.1 4区 医学 Q1 ECONOMICS
Min Fan, Anna-Janina Stephan, Michael Hanselmann, Andreas Lueg, Michael Laxy
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Abstract

Aim: The aim of this study was to analyse the real-world health and economic effect of an outpatient screening and continuing-care programme for early detection and care of microvascular complications in patients with type 2 diabetes (T2D) delivered through a selective contract between a large statutory health insurance company and ambulatory care physicians in the German health care system.

Methods: Building on methods of target trial emulation and programme impact evaluation, we used a quasi-experimental approach and health insurance claims data from 790,375 patients with T2D over a time horizon of 5.75 years. We applied a two-stage matching approach in which we exploited the staggered implementation of the selective contract across federal states in Germany to control for selection bias at the physician level and used propensity scores to control for selection bias at the patient level, where we considered socio-demographic, health consciousness-related, care-related, and comorbidity-related potential confounders in the matching process.

Results: Within a matched sample of 16,490 patients, over 1 year, enrolment into the programme increased the number of visits to primary care physicians (relative risk [RR]: 1.09, 95% confidence interval [CI] 1.07, 1.10), increased the frequency of prescriptions for sodium-glucose cotransporter-2 (SGLT2) inhibitors (RR: 1.30, 95% CI 1.12, 1.50) and for statins (RR: 1.08, 95% CI 1.03, 1.13) and decreased the risk of hospitalisations (RR: 0.88, 95% CI 0.84, 0.92). Outpatient costs in the enrolled patients were on average 14% (cost ratio: 1.14, 95% CI 1.09, 1.20) or €194.4 higher, but overall, the programme was budget neutral over a time horizon of 1 year.

Conclusion: Investing in secondary prevention to detect and manage the early stages of microvascular complications is likely a cost-effective or cost-saving approach to improve health in patients with T2D.

在德国实施的常规护理中,对2型糖尿病患者微血管并发症进行早期检测和护理的大规模门诊筛查和持续护理计划的现实世界健康和经济影响:一项使用健康保险索赔数据的准实验研究。
目的:本研究的目的是分析门诊筛查和持续护理方案对2型糖尿病(T2D)患者微血管并发症的早期发现和护理的现实健康和经济影响,该方案通过一家大型法定医疗保险公司和德国医疗保健系统中的门诊护理医生之间的选择性合同提供。方法:基于目标试验模拟和方案影响评估方法,我们采用准实验方法和健康保险索赔数据,这些数据来自790,375名T2D患者,时间跨度为5.75年。我们采用了两阶段匹配方法,其中我们利用德国联邦各州交错实施的选择性合同来控制医生水平的选择偏差,并使用倾向评分来控制患者水平的选择偏差,在匹配过程中我们考虑了社会人口统计学、健康意识相关、护理相关和合并症相关的潜在混杂因素。结果:在匹配的16490例患者样本中,在1年的时间里,纳入该计划的患者增加了对初级保健医生的就诊次数(相对风险[RR]: 1.09, 95%可信区间[CI] 1.07, 1.10),增加了钠-葡萄糖共转运蛋白-2 (SGLT2)抑制剂(RR: 1.30, 95% CI 1.12, 1.50)和他汀类药物(RR: 1.08, 95% CI 1.03, 1.13)的处方频率,降低了住院风险(RR: 0.88, 95% CI 0.84, 0.92)。入组患者的门诊费用平均为14%(成本比:1.14,95% CI 1.09, 1.20)或194.4欧元,但总体而言,该计划在1年的时间范围内预算中性。结论:投资二级预防以发现和管理早期微血管并发症可能是改善T2D患者健康的一种经济有效或节省成本的方法。
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来源期刊
Applied Health Economics and Health Policy
Applied Health Economics and Health Policy Economics, Econometrics and Finance-Economics and Econometrics
CiteScore
6.10
自引率
2.80%
发文量
64
期刊介绍: Applied Health Economics and Health Policy provides timely publication of cutting-edge research and expert opinion from this increasingly important field, making it a vital resource for payers, providers and researchers alike. The journal includes high quality economic research and reviews of all aspects of healthcare from various perspectives and countries, designed to communicate the latest applied information in health economics and health policy. While emphasis is placed on information with practical applications, a strong basis of underlying scientific rigor is maintained.
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