{"title":"Breast skin merkel cell carcinoma: a case report.","authors":"Xinming Hou, Qian Lv, Zhaobao Lv","doi":"10.62347/YFTJ3672","DOIUrl":null,"url":null,"abstract":"<p><p>Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin malignancy characterized by high recurrence and metastasis rates. Here, we present a case of primary breast skin MCC in a 65-year-old female patient who initially presented with a peanut-sized lump on her right breast, which rapidly developed into a cauliflower-like mass accompanied by intermittent pain. The patient underwent radical surgery (right mastectomy and right axillary lymph node dissection), followed by postoperative chemotherapy. Immunohistochemical examination revealed positive staining for Cytokeratin 20 (CK20), Synaptophysin (Syn), Cluster of Differentiation 56 (CD56), and Chromogranin A (CgA), confirming the diagnosis of MCC. A subsequent Positron Emission Tomography - Computed Tomography (PET-CT) scan revealed secondary liver metastasis. Despite an initial effective response to chemotherapy, the patient developed severe bone marrow suppression, necessitating a switch to maintenance therapy with capecitabine.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 5","pages":"3554-3559"},"PeriodicalIF":1.7000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170398/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of translational research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/YFTJ3672","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin malignancy characterized by high recurrence and metastasis rates. Here, we present a case of primary breast skin MCC in a 65-year-old female patient who initially presented with a peanut-sized lump on her right breast, which rapidly developed into a cauliflower-like mass accompanied by intermittent pain. The patient underwent radical surgery (right mastectomy and right axillary lymph node dissection), followed by postoperative chemotherapy. Immunohistochemical examination revealed positive staining for Cytokeratin 20 (CK20), Synaptophysin (Syn), Cluster of Differentiation 56 (CD56), and Chromogranin A (CgA), confirming the diagnosis of MCC. A subsequent Positron Emission Tomography - Computed Tomography (PET-CT) scan revealed secondary liver metastasis. Despite an initial effective response to chemotherapy, the patient developed severe bone marrow suppression, necessitating a switch to maintenance therapy with capecitabine.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
