Laurent Turner, Anjalee I Wanasinghe, Pamela Brunori, Sylvia Santosa
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引用次数: 0
Abstract
In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low-grade inflammation. Indeed, adipose tissue inflammation, which partially stems from macrophage infiltration and expression of macrophage-derived cytokines, has local and systemic consequences on health and increases the likelihood of developing obesity-associated comorbidities. In addition, cellular changes driven by macrophages may also further aggravate both adipose tissue dysfunction and inflammation, thus contributing to the onset and progression of several comorbidities including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease, osteoarthritis, some cancers, and dementia. The purpose of this review is to discuss how adipose tissue inflammation relates and contributes to the pathogenesis of obesity-associated comorbidities.
期刊介绍:
Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities.
Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field.
The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.