Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?

IF 8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Obesity Reviews Pub Date : 2025-06-18 DOI:10.1111/obr.13956
Laurent Turner, Anjalee I Wanasinghe, Pamela Brunori, Sylvia Santosa
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引用次数: 0

Abstract

In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low-grade inflammation. Indeed, adipose tissue inflammation, which partially stems from macrophage infiltration and expression of macrophage-derived cytokines, has local and systemic consequences on health and increases the likelihood of developing obesity-associated comorbidities. In addition, cellular changes driven by macrophages may also further aggravate both adipose tissue dysfunction and inflammation, thus contributing to the onset and progression of several comorbidities including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease, osteoarthritis, some cancers, and dementia. The purpose of this review is to discuss how adipose tissue inflammation relates and contributes to the pathogenesis of obesity-associated comorbidities.

脂肪组织炎症是肥胖相关合并症的元凶吗?
在肥胖个体中,慢性合并症的发作与脂肪组织在各种组织床中的过度积累相吻合。随着肥胖的发展,脂肪组织变得越来越功能失调,导致慢性低度炎症。事实上,脂肪组织炎症,部分源于巨噬细胞浸润和巨噬细胞源性细胞因子的表达,对健康有局部和全身的影响,并增加了发生肥胖相关合并症的可能性。此外,由巨噬细胞驱动的细胞变化也可能进一步加重脂肪组织功能障碍和炎症,从而导致几种合并症的发生和进展,包括2型糖尿病、心血管疾病、非酒精性脂肪性肝病、骨关节炎、某些癌症和痴呆。这篇综述的目的是讨论脂肪组织炎症如何与肥胖相关的合并症的发病机制有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Obesity Reviews
Obesity Reviews 医学-内分泌学与代谢
CiteScore
19.30
自引率
1.10%
发文量
130
审稿时长
1 months
期刊介绍: Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities. Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field. The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.
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