Repair of spinal cord injury using a time-specific four-dimensional multifunctional hydrogel with anti-inflammatory and neuronal differentiated microenvironments.

IF 5.8 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Ruizhi Zhang, Chenbo Zou, Linlin Jiang, Baoshuai Bai, Chunlin Li, Chi Zhang, Hua Zhao, Shaohui Zong, Hao Li, Kai Jiang, Hengxing Zhou, Shiqing Feng
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引用次数: 0

Abstract

Spinal cord injury (SCI) is a severe central nervous system (CNS) condition that often leads to permanent disability. The repair of SCI presents significant challenges globally, primarily due to serious inflammatory damage in the early stage and limited neural regeneration in the long-term stage. In response to these challenges, this study developed a novel time-specific four-dimensional multifunctional SilMA hydrogel (4DMSH) that releases Houttuynia cordata extract (HCT) in the early stage of post-implantation to combat inflammation and a sustained release of neurotrophin-3 (NT-3) in the long-term stage to promote neuronal differentiation of endogenous neural stem cells (eNSCs) for neuronal regeneration. As expected, the time-specific 4DMSH significantly mitigated inflammatory responses, leading to a shift from a pro-inflammatory to a neural regenerative environment, and enhanced the differentiation of eNSCs into neurons, thereby effectively improving the recovery of motor, sensory, and autonomic functions after SCI. Therefore, this study presents a novel time-specific 4DMSH that creates anti-inflammatory and neuroactive microenvironments, contributing to efficient neuronal regeneration and SCI repair.

具有抗炎和神经元分化微环境的时间特异性四维多功能水凝胶修复脊髓损伤。
脊髓损伤(SCI)是一种严重的中枢神经系统(CNS)疾病,经常导致永久性残疾。在全球范围内,脊髓损伤的修复面临着巨大的挑战,主要是由于早期严重的炎症损伤和长期的神经再生有限。为了应对这些挑战,本研究开发了一种新型的时间特异性四维多功能SilMA水凝胶(4DMSH),该凝胶在植入后早期释放鱼腥草提取物(HCT)以对抗炎症,并在长期阶段持续释放神经营养因子-3 (NT-3)以促进内源性神经干细胞(eNSCs)的神经元分化以实现神经元再生。正如预期的那样,时间特异性的4DMSH显著减轻了炎症反应,导致从促炎环境向神经再生环境的转变,并增强了eNSCs向神经元的分化,从而有效地促进了脊髓损伤后运动、感觉和自主神经功能的恢复。因此,本研究提出了一种新的时间特异性4DMSH,它可以创造抗炎和神经活性微环境,有助于有效的神经元再生和脊髓损伤修复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomaterials Science
Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.50%
发文量
556
期刊介绍: Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.
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