Relationship between structural brain differences and social factors associated with neurodevelopmental disorders: A systematic review

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2025-06-19 DOI:10.1016/j.neubiorev.2025.106266

Celia Maria Araujo , Matheus Ghossain Barbosa , Aline Camargo Ramos , Vinicius Oliveira Santana , Ivaldo Silva , Anders Nordahl-Hansen , Andrea Parolin Jackowski

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Abstract

Advances in neuroimaging have substantially improved our understanding of the biological mechanisms underlying neurodevelopment. Although relevant studies are scarce, social determinants, particularly socioeconomic status (SES) appears to play a crucial role in typical and atypical brain development. Different methods and scales are used to evaluate SES. The aim of this systematic review was to investigate the influence of SES on brain structure in neurodevelopmental disorders (NDDs) and its potential impact on the diagnosis and severity of NDDs. The 1423 entries extracted from six databases were imported into Covidence, and 13 (7 cohort, 4 case-control, and 2 cross-sectional) studies were included in our final synthesis, encompassing a combined sample of 33,789 participants. The SES indicators used by the studies included measures of income, residential neighbourhood, and educational levels and seem to be associated with structural changes in neurodevelopment throughout life. During the early stages of development, maternal SES impacts children's brain structure and behavioural and cognitive outcomes. At older ages, parental schooling continues to be a determining factor for cognitive performance, while differences in brain structure become more evident and associated with NDDs such as attention deficit/hyperactivity disorder.

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脑结构差异与神经发育障碍相关社会因素的关系：系统综述

神经影像学的进步大大提高了我们对神经发育生物学机制的理解。尽管相关研究很少，但社会决定因素，特别是社会经济地位（SES）似乎在典型和非典型大脑发育中起着至关重要的作用。不同的方法和量表用于评估SES。本系统综述旨在探讨SES对神经发育障碍（ndd）患者脑结构的影响及其对ndd诊断和严重程度的潜在影响。从6个数据库中提取的1423个条目被导入到《covid - ence》中，13项研究（7项队列研究、4项病例对照研究和2项横断面研究）被纳入我们的最终综合研究，包括33,789名参与者的总样本。研究中使用的社会经济地位指标包括收入、居住社区和教育水平，似乎与一生中神经发育的结构变化有关。在发育的早期阶段，母亲的SES会影响儿童的大脑结构以及行为和认知结果。在年龄较大时，父母的教育仍然是认知表现的决定性因素，而大脑结构的差异变得更加明显，并与ndd（如注意缺陷/多动障碍）相关。

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.