Safety and efficacy of endoscopic sleeve gastroplasty after liver transplantation

iGIE Pub Date : 2025-06-01 DOI:10.1016/j.igie.2025.03.013

Benjamin I. Richter MD , Yazan Abboud MD , Jay Phansalkar BS , Keri E. Lunsford MD, PhD , Zaid Tafesh MD , Arpit Amin MD , Dhvani Dosh MD, MPH , Ahmed Al-Khazraji MD , Suut Gokturk MD , Paul Gaglio MD , Kaveh Hajifathalian MD, MPH

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Abstract

Background and Aims

Obesity after liver transplantation (LT) can compromise patient outcomes. We report safety and efficacy data on endoscopic sleeve gastroplasty (ESG) after LT.

Methods

This is a retrospective case series of patients who underwent ESG after LT.

Results

All 5 patients underwent ESG at a median 47.3 months (interquartile range [IQR], 34.4-67.4 months) after LT. Patients were predominantly male (4/5, 80%) with median age 61 years (IQR, 51-61 years) and preoperative body mass index 38.8 kg/m² (IQR, 37.1-42.6 kg/m²). Median follow-up after ESG was 18.8 months (IQR, 8.2-19.8 months). Median total body weight loss was 27.2% (IQR, 8.0%-30.0%) at the end of follow-up. Weight loss plateau occurred in 2 patients, with 5 postoperative adverse events in 4 patients (80%) that were mild, and none exceeded grade I on the Clavien-Dindo scale. No patient missed doses of immunosuppressive medications. Liver graft function remained stable.

Conclusions

Our data support the use of ESG after LT, although more data are needed to validate our findings.

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肝移植术后内镜下袖胃成形术的安全性和有效性

背景和目的肝移植术后肥胖会影响患者的预后。结果5例患者均在lt后中位47.3个月（四分位间距[IQR]， 34.4-67.4个月）接受了ESG治疗。患者以男性为主（4/ 5,80%），中位年龄61岁（IQR， 51-61岁），术前体重指数38.8 kg/m2 （IQR, 37.1-42.6 kg/m2）。ESG术后中位随访时间为18.8个月（IQR, 8.2-19.8个月）。随访结束时，中位总体重减轻27.2% （IQR, 8.0%-30.0%）。2例患者出现体重下降平台期，4例患者（80%）出现5例术后不良事件，均为轻度，均未超过Clavien-Dindo分级I级。没有患者漏服免疫抑制药物。肝移植功能保持稳定。sour数据支持肝移植后ESG的使用，尽管需要更多的数据来验证我们的发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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iGIE

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