Transition-metal-free methylthiolation of aryl fluorides with S-methylisothiourea sulfate in PEG-400

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-06-13 DOI:10.1016/j.tet.2025.134785

Xiangmei Wu, Dayun Huang

引用次数: 0

Abstract

A simple method for methylthiolation has been developed to produce various aryl methyl sulfides in moderate to good yields. This method uses inexpensive aryl fluorides as starting materials and S-methylisothiourea sulfate as the thiomethyl source. Halogen atoms like iodine, bromine, and chlorine are well tolerated. This simplifies further product transformations. Besides, this approach is catalyst-free. The reaction conditions are simple, the starting materials are readily available, and the solvent used is PEG-400, making the system more environmentally friendly.

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用s -甲基异硫脲硫酸盐在PEG-400中对芳基氟化物进行无过渡金属甲基硫代化

开发了一种简单的甲基硫代化方法，以中高收率生产各种芳基甲基硫化物。该方法使用廉价的芳基氟化物作为起始原料，s -甲基异硫脲硫酸盐作为硫甲基源。像碘、溴和氯这样的卤素原子耐受性很好。这简化了进一步的乘积变换。此外，这种方法不需要催化剂。反应条件简单，起始原料容易获得，溶剂为PEG-400，使体系更加环保。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.