Direct C–H aminocarbonylation of quinone derivatives with isocyanides under transition-metal free conditions

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-06-14 DOI:10.1016/j.tet.2025.134779

Yingjie Zhang, Yuxuan Zhao, Jiankang Ou, Zeguo Fang, Qian Zhang, Dong Li

引用次数: 0

Abstract

An efficient and facile C–H aminocarbonylation of quinone derivatives with isocyanides for the synthesis of corresponding amides was developed. This reaction was promoted by inorganic persulfate under transition-metal free conditions. A broad substrate scope including quinoxalines and quinoxalinones were exhibited by this method, affording the corresponding amides in moderated to good yields.

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醌类衍生物与异氰酸酯在无过渡金属条件下的直接C-H氨基羰基化反应

研究了醌类衍生物与异氰酸酯的C-H氨基羰基化反应。在无过渡金属的条件下，无机过硫酸盐促进了该反应。通过该方法，可以得到广泛的底物范围，包括喹诺啉类和喹诺啉酮类，并可获得相应的酰胺类，收率较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.