Ultrasonically assisted synthesis of Co-Ni bimetallic oxides for simultaneous detection of furazolidone and metronidazole

IF 8.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry Pub Date : 2025-06-16 DOI:10.1016/j.ultsonch.2025.107433

Rijia Liu , Bolin Wu , Changru Xu , Chaojun Zhang , Meng Han , Meiting Zhao , Wein-Duo Yang , Rui Liu

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Abstract

This work developed an ultrasonically assisted synthesis of nickel cobaltite (NiCo₂O₄) modified electrode for simultaneous detection of Furazolidone (FRZ) and Metronidazole (MTR) in biological samples. The structural and chemical properties of the as-prepared electrodes were systematically characterized through multiple analytical techniques. The NiCo₂O₄-modified glassy carbon electrode (NiCo₂O₄/GCE) demonstrated exceptional performance with wide linear ranges of 0.005–200 μM for MTR and 0.01–150 μM for FRZ, with remarkably low detection limits of 2.57 nM and 29.13 nM, respectively. The sensor exhibited excellent selectivity against common interferents, good reproducibility, and maintained > 90 % activity after 30 days. NiCo₂O₄/GCE can be used to detect MTR and FRZ in real pharmaceutical and serum samples, achieving excellent recovery rates within the range of 94.0 % to 114.0 %. This work not only presents a superior sensing platform for antibiotic monitoring but also establishes ultrasound-assisted synthesis as an effective strategy for developing advanced bimetallic oxide electrocatalysts.

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超声辅助合成Co-Ni双金属氧化物同时检测呋喃唑酮和甲硝唑

建立了一种超声辅助合成的钴酸镍修饰电极，用于同时检测生物样品中的呋喃唑酮（FRZ）和甲硝唑（MTR）。通过多种分析技术系统地表征了所制备电极的结构和化学性质。NiCo2O4修饰的玻碳电极（NiCo2O4/GCE）表现出优异的性能，其MTR线性范围为0.005 ~ 200 μM， FRZ线性范围为0.01 ~ 150 μM，检出限分别为2.57 nM和29.13 nM。该传感器对常见干扰具有良好的选择性、良好的再现性和良好的稳定性。30天后90%的活动。NiCo2O4/GCE可用于检测真实药物和血清样品中的MTR和FRZ，回收率在94.0% ~ 114.0%之间。这项工作不仅为抗生素监测提供了一个优越的传感平台，而且为开发先进的双金属氧化物电催化剂建立了超声辅助合成的有效策略。

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来源期刊

Ultrasonics Sonochemistry 化学-化学综合

CiteScore

15.80

自引率

11.90%

发文量

361

审稿时长

59 days

期刊介绍： Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels. Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.