Global Trends in Ischemic Heart Disease-Related Mortality From 2000 to 2019

JACC advances Pub Date : 2025-06-19 DOI:10.1016/j.jacadv.2025.101904

Vikash Jaiswal MD , Jef Van den Eynde MD , Yusra Mashkoor MBBS , Helen Huang MBBCh , Vamsi Garimella MD , Sulochana Khadka MD , Tushar Kumar MD , Akash Jaiswal MD , Wilbert Aronow MD , Maciej Banach MD, PhD , Gregg C. Fonarow MD

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Abstract

Background

Ischemic heart disease (IHD) remains one of the leading causes of morbidity and mortality across the globe, and disparities exist based on sex and geographic region.

Objectives

This study investigates global trends in IHD mortality and examines disparities based on sex and geographic regions.

Methods

IHD mortality data from 105 countries were obtained from the World Health Organization Mortality Database. Crude mortality rates (CMRs) and age-standardized mortality rates (ASMRs) per 100,000 individuals were calculated, with average annual percentage change (AAPC) analyzed using joinpoint regression. Regional and sex-specific trends were assessed using stratified analyses of CMR and ASMR.

Results

Globally, CMR declined from 138 per 100,000 (95% CI: 131-145) in 2000 to 106 per 100,000 (95% CI: 102-114) in 2019 (AAPC: −1.79, 95% CI: −1.93 to −1.66). Similarly, ASMR declined from 104 per 100,000 (95% CI: 99-108) to 65.5 (95% CI: 62-69) in 2019 per 100,000 (AAPC: −2.16, 95% CI: −2.13 to −2.20). Regionally, CMRs decreased in Oceania, Europe, and North America, while they rose in Asia, Africa, and Central and South America. ASMRs declined worldwide except in Africa (AAPC: 1.33, 95% CI: 1.30-1.36). Males showed higher mortality than females, but both sexes demonstrated decreasing trends, with males having a steeper decline. In age groups across all regions, Africa showed an upward trend, while other regions demonstrated declines.

Conclusions

While global IHD mortality has declined from 2000 to 2019, disparities by geographic region and sex persist. Implementing targeted health awareness programs and collaborative global health efforts are crucial for addressing these inequalities.

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2000 - 2019年缺血性心脏病相关死亡率的全球趋势

非化学性心脏病（IHD）仍然是全球发病率和死亡率的主要原因之一，性别和地理区域存在差异。目的本研究调查了IHD死亡率的全球趋势，并检查了基于性别和地理区域的差异。方法从世界卫生组织死亡率数据库中获取105个国家的hd死亡率数据。计算每10万人的粗死亡率（CMRs）和年龄标准化死亡率（ASMRs），并使用连接点回归分析平均年百分比变化（AAPC）。使用CMR和ASMR的分层分析评估区域和性别特异性趋势。在全球范围内，CMR从2000年的138 / 10万（95% CI: 131-145）下降到2019年的106 / 10万（95% CI: 102-114）（AAPC: - 1.79, 95% CI: - 1.93至- 1.66）。同样，ASMR从10万分之104 （95% CI: 99-108）下降到2019年的10万分之65.5 (95% CI: 62-69) （AAPC: - 2.16, 95% CI: - 2.13至- 2.20）。从区域来看，cmr在大洋洲、欧洲和北美下降，而在亚洲、非洲和中南美洲上升。除非洲外，asmr在全球范围内下降（AAPC: 1.33, 95% CI: 1.30-1.36）。男性的死亡率高于女性，但两性都呈现下降趋势，其中男性的下降幅度更大。在所有区域的年龄组中，非洲呈现上升趋势，而其他区域则呈现下降趋势。结论：虽然全球IHD死亡率从2000年到2019年有所下降，但地理区域和性别之间的差异仍然存在。实施有针对性的卫生宣传方案和全球卫生合作努力对于解决这些不平等问题至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JACC advances Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

发文量