Systematic evaluation of the associations between schizophrenia and autoimmune diseases: An umbrella review

IF 9.2 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2025-06-16 DOI:10.1016/j.autrev.2025.103854

Zhouyang Sun, Beibei Han, Qianlu Ding, Yuan Feng, Tingyi Jia, Yixin Ouyang, Xinru Guo, Jingyi Liang, Qianlong Huang, Changgui Kou , Wei Bai

{"title":"Systematic evaluation of the associations between schizophrenia and autoimmune diseases: An umbrella review","authors":"Zhouyang Sun, Beibei Han, Qianlu Ding, Yuan Feng, Tingyi Jia, Yixin Ouyang, Xinru Guo, Jingyi Liang, Qianlong Huang, Changgui Kou , Wei Bai","doi":"10.1016/j.autrev.2025.103854","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to assess research trends in the association between schizophrenia and autoimmune diseases, systematically review their relationship, and evaluate the credibility of existing evidence.</div></div><div><h3>Methods</h3><div>Bibliometric analysis was conducted using the bibliometrix package in R, along with VOSviewer and CiteSpace. Relevant systematic reviews and meta-analyses were retrieved from six databases: PubMed, Web of Science, Embase, CINAHL, PsycINFO, and the Cochrane Library. Summary risk estimates were recalculated using the DerSimonian and Laird method under a random-effects model, and the credibility of the evidence was assessed.</div></div><div><h3>Results</h3><div>The bibliometric analysis found that “meta-analysis” has become a frequently used keyword and may be a focal point for future research. The umbrella review included 17 articles, containing 24 report data points from 12 quantitative reviews. Results indicated that 9 reports assessed the relationship between schizophrenia and autoimmune diseases. Schizophrenia was significantly associated with autoimmune neurological disorders <em>(RR</em> = 1.42; 95 % <em>CI</em> = 1.18–1.72), providing suggestive evidence. Seven reports evaluated the impact of schizophrenia on autoimmune diseases, showing highly suggestive evidence that schizophrenia patients had a pooled relative risk of 2.22 (95 % <em>CI</em> = 1.95–2.52) for psoriasis. Eight reports assessed the impact of autoimmune diseases on schizophrenia, with bullous pemphigoid patients showing significantly higher schizophrenia prevalence (<em>OR</em> = 2.63; 95 % <em>CI</em> = 2.03–3.39).</div></div><div><h3>Conclusions</h3><div>This study synthesizes evidence of varying levels, highlighting the association between schizophrenia and autoimmune diseases. It offers new insights for future exploration, fosters interdisciplinary collaboration, and provides valuable implications for public health policy development.</div></div>","PeriodicalId":8664,"journal":{"name":"Autoimmunity reviews","volume":"24 9","pages":"Article 103854"},"PeriodicalIF":9.2000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autoimmunity reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1568997225001144","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

This study aims to assess research trends in the association between schizophrenia and autoimmune diseases, systematically review their relationship, and evaluate the credibility of existing evidence.

Methods

Bibliometric analysis was conducted using the bibliometrix package in R, along with VOSviewer and CiteSpace. Relevant systematic reviews and meta-analyses were retrieved from six databases: PubMed, Web of Science, Embase, CINAHL, PsycINFO, and the Cochrane Library. Summary risk estimates were recalculated using the DerSimonian and Laird method under a random-effects model, and the credibility of the evidence was assessed.

Results

The bibliometric analysis found that “meta-analysis” has become a frequently used keyword and may be a focal point for future research. The umbrella review included 17 articles, containing 24 report data points from 12 quantitative reviews. Results indicated that 9 reports assessed the relationship between schizophrenia and autoimmune diseases. Schizophrenia was significantly associated with autoimmune neurological disorders (RR = 1.42; 95 % CI = 1.18–1.72), providing suggestive evidence. Seven reports evaluated the impact of schizophrenia on autoimmune diseases, showing highly suggestive evidence that schizophrenia patients had a pooled relative risk of 2.22 (95 % CI = 1.95–2.52) for psoriasis. Eight reports assessed the impact of autoimmune diseases on schizophrenia, with bullous pemphigoid patients showing significantly higher schizophrenia prevalence (OR = 2.63; 95 % CI = 2.03–3.39).

Conclusions

This study synthesizes evidence of varying levels, highlighting the association between schizophrenia and autoimmune diseases. It offers new insights for future exploration, fosters interdisciplinary collaboration, and provides valuable implications for public health policy development.

查看原文本刊更多论文

精神分裂症与自身免疫性疾病相关性的系统评价：概括性综述

目的本研究旨在评估精神分裂症与自身免疫性疾病相关性的研究趋势，系统回顾两者之间的关系，并评估现有证据的可信度。方法使用R中的bibliometrix软件包，以及VOSviewer和CiteSpace进行文献计量学分析。相关的系统综述和荟萃分析从六个数据库检索：PubMed、Web of Science、Embase、CINAHL、PsycINFO和Cochrane图书馆。在随机效应模型下，使用DerSimonian和Laird方法重新计算总结风险估计，并评估证据的可信度。结果文献计量分析发现，“元分析”已成为一个频繁使用的关键词，并可能成为未来研究的重点。总括性审查包括17篇文章，包含来自12个定量审查的24个报告数据点。结果显示，9份报告评估了精神分裂症与自身免疫性疾病的关系。精神分裂症与自身免疫性神经系统疾病显著相关(RR = 1.42；95% CI = 1.18-1.72)，提供了启发性证据。七份报告评估了精神分裂症对自身免疫性疾病的影响，显示出高度暗含性的证据，精神分裂症患者患牛皮癣的总相对风险为2.22 （95% CI = 1.95-2.52）。8份报告评估了自身免疫性疾病对精神分裂症的影响，大疱性类天疱疮患者的精神分裂症患病率明显更高(OR = 2.63；95% ci = 2.03-3.39)。本研究综合了不同水平的证据，强调了精神分裂症与自身免疫性疾病之间的关联。它为未来的探索提供了新的见解，促进了跨学科合作，并为公共卫生政策的制定提供了宝贵的启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.