Concentration Indicator Kit Based on Dandelion Propagation-Inspired SERS Strategy.

IF 27.4 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Guoqian Li,Langlang Yi,Shiya Zhang,Qin Song,Minghui Liang,Zhihui Guan,Yao Zhang,Yuan Zhuang,Bo Hou,Xinyuan Wang,Xiaoyao Wu,Pengju Yin,Klyuyev Dmitriy,Jiang Yang,Bo Hu,Jie Tian
{"title":"Concentration Indicator Kit Based on Dandelion Propagation-Inspired SERS Strategy.","authors":"Guoqian Li,Langlang Yi,Shiya Zhang,Qin Song,Minghui Liang,Zhihui Guan,Yao Zhang,Yuan Zhuang,Bo Hou,Xinyuan Wang,Xiaoyao Wu,Pengju Yin,Klyuyev Dmitriy,Jiang Yang,Bo Hu,Jie Tian","doi":"10.1002/adma.202502162","DOIUrl":null,"url":null,"abstract":"Surface-enhanced Raman scattering (SERS) technology has been extensively employed for the detection of liquid samples in the biomedical field due to high sensitivity and non-invasive characteristics. However, quantitative SERS detection is hindered by sophisticated instrumentation and complex calibration procedures, while qualitative analyses often provide insufficient concentration information for clinical diagnosis. Herein, a concentration indicator kit based on dandelion propagation-inspired SERS strategy is developed for the semi-quantitative detection of drug residues in urine. This strategy achieves significant signal enhancement through the synergistic effects of optimized hotspot construction and molecular adsorption, resulting in an analytical enhancement factor of 2.503 × 10⁵, which is 4143 times greater than that of silver nanoparticles. An innovative phenomenon termed the \"concentration indicator\" is discovered, wherein the SERS signal is dramatically enhanced at specific indicated concentrations while remaining weak at adjacent concentrations. The practical utility of this kit is validated through the detection of 2-mercaptobenzothiazole in urine samples. The kit exhibits excellent performance in semi-quantitative detection of standard solutions and simulated samples at high, indicated, and low concentrations. The concentration indicator opens new avenues for the development of simplified and reliable SERS-based detection, offering a promising platform for bedside testing in medical diagnostics.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"21 1","pages":"e2502162"},"PeriodicalIF":27.4000,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/adma.202502162","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Surface-enhanced Raman scattering (SERS) technology has been extensively employed for the detection of liquid samples in the biomedical field due to high sensitivity and non-invasive characteristics. However, quantitative SERS detection is hindered by sophisticated instrumentation and complex calibration procedures, while qualitative analyses often provide insufficient concentration information for clinical diagnosis. Herein, a concentration indicator kit based on dandelion propagation-inspired SERS strategy is developed for the semi-quantitative detection of drug residues in urine. This strategy achieves significant signal enhancement through the synergistic effects of optimized hotspot construction and molecular adsorption, resulting in an analytical enhancement factor of 2.503 × 10⁵, which is 4143 times greater than that of silver nanoparticles. An innovative phenomenon termed the "concentration indicator" is discovered, wherein the SERS signal is dramatically enhanced at specific indicated concentrations while remaining weak at adjacent concentrations. The practical utility of this kit is validated through the detection of 2-mercaptobenzothiazole in urine samples. The kit exhibits excellent performance in semi-quantitative detection of standard solutions and simulated samples at high, indicated, and low concentrations. The concentration indicator opens new avenues for the development of simplified and reliable SERS-based detection, offering a promising platform for bedside testing in medical diagnostics.
基于蒲公英繁殖诱导SERS策略的浓度指标试剂盒。
表面增强拉曼散射(SERS)技术具有灵敏度高、无创等特点,已广泛应用于生物医学领域的液体样品检测。然而,定量SERS检测受到精密仪器和复杂校准程序的阻碍,而定性分析通常无法提供临床诊断所需的浓度信息。本研究开发了一种基于蒲公英繁殖激发SERS策略的浓度指标试剂盒,用于半定量检测尿液中药物残留。该策略通过优化的热点构建和分子吸附的协同效应实现了显著的信号增强,导致分析增强因子为2.503 × 10 5,是银纳米颗粒的4143倍。一种被称为“浓度指示器”的创新现象被发现,其中SERS信号在特定指示浓度下显着增强,而在邻近浓度下保持微弱。通过检测尿样中的2-巯基苯并噻唑,验证了该试剂盒的实用性。该试剂盒在高、指示和低浓度的标准溶液和模拟样品的半定量检测中表现出优异的性能。该浓度指标为开发简化可靠的基于sers的检测开辟了新的途径,为医学诊断中的床边检测提供了一个有前景的平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Advanced Materials
Advanced Materials 工程技术-材料科学:综合
CiteScore
43.00
自引率
4.10%
发文量
2182
审稿时长
2 months
期刊介绍: Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信