Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains.

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-06-18 DOI:10.1083/jcb.202505027

Sabina Elmi,Jesper Nylandsted

引用次数: 0

Abstract

In this issue, Williams et al. (https://doi.org/10.1083/jcb.202408159) reveal a two-step plasma membrane repair process upon injury: annexins first stabilize damage sites, then calcium-activated calpains cleave these patches, triggering microvesicle shedding-mirroring the clot-and-scab resolution seen in tissue-level wound healing.

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细胞伤口愈合：膜联蛋白和钙蛋白的两步质膜修复机制。

在这期杂志上，Williams等人（https://doi.org/10.1083/jcb.202408159）揭示了损伤后的两步质膜修复过程：膜联蛋白首先稳定损伤部位，然后钙活化钙蛋白酶裂解这些斑块，触发微囊脱落，这反映了组织水平伤口愈合中看到的凝块和结痂的溶解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.