Organelle conversations drive ferroptosis

IF 19.1 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-06-19 DOI:10.1038/s41556-025-01694-x

Ancély Ferreira dos Santos, José Pedro Friedmann Angeli

引用次数: 0

Abstract

Ferroptosis begins with phospholipid peroxidation, leading to membrane damage rupture and cell death. Although research has surged, the intracellular site for ferroptosis initiation remains uncertain. A study now identifies endoplasmic reticulum–mitochondria appositions as key hubs for phospholipid peroxides and important determinants of ferroptosis sensitivity.

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细胞器对话驱动铁下垂

铁下垂开始于磷脂过氧化，导致膜损伤破裂和细胞死亡。尽管研究已经激增，但铁下垂的细胞内起始位点仍然不确定。一项研究现在确定内质网-线粒体的结合是磷脂过氧化物的关键枢纽和铁下垂敏感性的重要决定因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology