The oesophagus as an immune organ

IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Mark Rochman, Kendall Kellerman, Michael P. Jankowski, Marc E. Rothenberg
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引用次数: 0

Abstract

The oesophagus has traditionally been viewed as a simple conduit for food transport. In performing this delivery function, it confronts a continuous influx of foreign antigens, including food particles with variable microbial content, and encounters many biophysical stimuli triggered by food textures and temperature. To meet these challenges, the oesophagus comprises a robust barrier featuring a thick, multilayered epithelium coated by mucins and mechanically held together by strong adhesion complexes, including desmosomal junctions. Sentinel immune cells, including a notable presence of CD8+ resident memory T cells, mast cells and dendritic cells, are abundant alongside IL-1 family cytokines released and activated under tight homeostatic regulation through a balance of proteases and antiproteases. Pattern recognition receptors, such as Toll-like receptors on epithelial cells, identify foreign antigens and can trigger cytokine release. Disruptions, whether acquired or genetically inherited, in these innate immune functions contribute to disease onset. Here, we present evidence that the oesophagus is an immune organ with extensive sensing properties designed to tolerate and mount defences against antigenic and biophysical challenges.

Abstract Image

食道作为免疫器官
食道传统上被认为是食物运输的简单管道。在执行这种递送功能时,它要面对外来抗原的持续涌入,包括微生物含量变化的食物颗粒,并遇到由食物质地和温度引发的许多生物物理刺激。为了应对这些挑战,食道包括一个坚固的屏障,其特征是由粘蛋白包裹的厚的多层上皮,并通过强粘附复合物(包括桥粒连接)机械地结合在一起。前哨免疫细胞,包括CD8+常驻记忆T细胞、肥大细胞和树突状细胞的显著存在,与IL-1家族细胞因子一起丰富,在蛋白酶和抗蛋白酶平衡的严格稳态调节下释放和激活。模式识别受体,如上皮细胞上的toll样受体,识别外来抗原并能触发细胞因子释放。这些先天免疫功能的破坏,无论是后天的还是遗传的,都有助于疾病的发作。在这里,我们提出的证据表明,食道是一个免疫器官,具有广泛的传感特性,旨在容忍和防御抗原和生物物理挑战。
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来源期刊
CiteScore
52.30
自引率
0.60%
发文量
147
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.
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