Racial/Ethnic Differences in the Joint Effect of Edentulism and Diabetes on All-Cause Mortality Risks: A 12-Year Prospective Cohort Analysis.

IF 1.5
Xiang Qi, Chenxin Tan, Huabin Luo, Brenda L Plassman, Frank A Sloan, Angela R Kamer, Mark D Schwartz, Bei Wu
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Abstract

Objectives: Edentulism and diabetes mellitus (DM) are frequently seen among older adults. However, the joint effect of edentulism and DM on mortality was understudied. We aim to examine the joint effect of edentulism and DM on all-cause mortality and to what extent the joint effect varies by race/ethnicity.

Methods: Analysis of US Health and Retirement Study (HRS) data (2006-2018) included 11,813 non-Hispanic Whites, 2216 non-Hispanic Blacks, and 1337 Hispanics aged ≥ 50 years old. Mortality data came from the National Death Index or HRS surveys. Edentulism was self-reported and DM was determined by self-reported diagnosis, medication use, or glycosylated hemoglobin. Cox proportional-hazard models with inverse probability treatment weighting were applied.

Results: During mean follow-up of 9.6 years, 2874 Whites, 703 Blacks, and 441 Hispanics died. DM was associated with higher mortality across all groups (Whites: HR = 1.43, 95% CI = 1.25-1.64; Blacks: HR = 1.62, 95% CI = 1.28-2.04; Hispanics: HR = 1.46, 95% CI = 1.07-1.99). However, edentulism predicted higher mortality only in Whites (HR = 1.65, 95% CI = 1.51-1.80). Having both conditions showed highest mortality risk in all groups (Whites: HR = 2.31, 95% CI = 1.56-3.42; Blacks: HR = 1.94, 95% CI = 1.45-2.59; Hispanics: HR = 1.77, 95% CI = 1.16-2.70), with a significant additive interaction observed only in Whites (relative excess risk due to interaction = 0.22, p < 0.05).

Conclusions: DM and edentulism pose an additive risk for mortality in Whites, and there are racial/ethnic differences in edentulism-related mortality.

一项为期12年的前瞻性队列分析:牙髓病和糖尿病对全因死亡风险共同影响的种族/民族差异
目的:牙髓病和糖尿病(DM)在老年人中很常见。然而,对全牙磨牙和糖尿病对死亡率的共同影响尚未得到充分研究。我们的目的是检查登牙和糖尿病对全因死亡率的共同影响,以及这种共同影响在多大程度上因种族/民族而异。方法:分析美国健康与退休研究(HRS)数据(2006-2018),包括11,813名非西班牙裔白人,2216名非西班牙裔黑人和1337名年龄≥50岁的西班牙裔。死亡率数据来自国家死亡指数或HRS调查。牙髓症是自我报告的,糖尿病是通过自我报告的诊断、药物使用或糖化血红蛋白来确定的。采用逆概率处理加权的Cox比例风险模型。结果:在平均9.6年的随访中,2874名白人、703名黑人和441名西班牙裔死亡。在所有组中,糖尿病与较高的死亡率相关(白人:HR = 1.43, 95% CI = 1.25-1.64;黑人:HR = 1.62, 95% CI = 1.28-2.04;西班牙裔:HR = 1.46, 95% CI = 1.07-1.99)。然而,只有白人患牙补牙症的死亡率较高(HR = 1.65, 95% CI = 1.51-1.80)。同时患有这两种疾病的所有组的死亡风险最高(白人:HR = 2.31, 95% CI = 1.56-3.42;黑人:HR = 1.94, 95% CI = 1.45-2.59;西班牙裔:HR = 1.77, 95% CI = 1.16-2.70),仅在白人中观察到显著的加性相互作用(由于相互作用而产生的相对超额风险= 0.22,p)。结论:糖尿病和牙髓病对白人的死亡率构成加性风险,牙髓病相关的死亡率存在种族/民族差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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