Role of Adipose Tissue Compartments for Cardiovascular Risk in Diabetes Endotypes.

IF 16.6

Diabetes care Pub Date : 2025-06-17 DOI:10.2337/dc24-2023

Oana-Patricia Zaharia, Yuliya Kupriyanova, Pavel Bobrov, Christian Binsch, Birgit Knebel, Tim Mori, Iryna Yurchenko, Dania Marel Mendez Cardenas, Theresa Kössler, Nina Trinks, Martin Schön, Kálmán B Bódis, Robert Wagner, Vera Schrauwen-Hinderling, Michael Roden

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Abstract

Objective: The severe insulin-resistant diabetes (SIRD) endotype is associated with metabolic dysfunction-associated steatotic liver disease and higher cardiovascular risk. We investigated whether skeletal muscle or adipose tissue lipids are elevated in SIRD.

Research design and methods: Participants (N = 420) of the German Diabetes Study (GDS) were assigned to diabetes clusters using a validated algorithm. 1H-magnetic resonance methods were used to quantify intramyocellular lipids (IMCLs), intrahepatic lipids (IHLs), and visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes.

Results: Aside from elevated IHLs (P < 0.01), SIRD showed higher VAT and SAT than other endotypes after adjustment for BMI (all P < 0.05) but not for multiple comparisons. All endotypes featured comparable IMCLs. VAT volume and IHLs correlated with cardiovascular risk scores (Framingham r = 0.661 and 0.548, respectively, P < 0.05). Polygenic risk scores for VAT were associated with higher cardiovascular risk.

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脂肪组织隔室在糖尿病内型心血管风险中的作用。

目的：重度胰岛素抵抗型糖尿病（SIRD）内型与代谢功能障碍相关的脂肪变性肝病和更高的心血管风险相关。我们研究了SIRD中骨骼肌或脂肪组织脂质是否升高。研究设计和方法：使用经过验证的算法将德国糖尿病研究（GDS）的参与者（N = 420）分配到糖尿病组。采用1h磁共振方法量化细胞内脂质（IMCLs）、肝内脂质（IHLs）、内脏脂肪组织（VAT）和皮下脂肪组织（SAT）体积。结果：除IHLs升高（P < 0.01）外，调整BMI后SIRD的VAT和SAT均高于其他内型（P < 0.05），但多重比较无差异。所有内型均具有可比性的imcl。VAT容积和IHLs与心血管危险评分相关（Framingham r分别为0.661和0.548,P < 0.05）。VAT的多基因风险评分与较高的心血管风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes care

CiteScore

29.50

自引率

0.00%

发文量