Addressing challenges in microbial manufacturing: Systematic microbial biotechnology.

IF 25.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

The Innovation Pub Date : 2025-03-07 eCollection Date: 2025-06-02 DOI:10.1016/j.xinn.2025.100871

Lijuan Liu, Fan Wang, Lei Wang, Xinglin Jiang, Haibo Zhang

{"title":"Addressing challenges in microbial manufacturing: Systematic microbial biotechnology.","authors":"Lijuan Liu, Fan Wang, Lei Wang, Xinglin Jiang, Haibo Zhang","doi":"10.1016/j.xinn.2025.100871","DOIUrl":null,"url":null,"abstract":"<p><p>Microbial manufacturing offers an alternative approach to producing chemicals and materials in a sustainable and environmentally friendly manner. Despite its significance and widespread attention, various challenges persist in its industrial application. We propose a systematic approach to microbial biotechnology-a comprehensive framework for developing customized technologies tailored to the unique characteristics of the entire process for specific products. It utilizes approaches such as simplifying the process, sequential rearrangement, and coupling steps to systematically and holistically address the bottlenecks of the entire process in microbial manufacturing, aiming to achieve optimal economic and environmental benefits. This method involves the integration of multiple disciplines, including enzymology, synthetic biology, metabolic engineering, fermentation, separation engineering, and artificial intelligence (AI) technology. Here, we present several cases involving various stages of product bioproduction, developed under the concept of systematic microbial biotechnology, to demonstrate its effectiveness and advantages. The development and application of these technological concepts hold significant potential to shape the future of a sustainable circular bioeconomy driven by microbial manufacturing.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"6 6","pages":"100871"},"PeriodicalIF":25.7000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169249/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Innovation","FirstCategoryId":"95","ListUrlMain":"https://doi.org/10.1016/j.xinn.2025.100871","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/2 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Microbial manufacturing offers an alternative approach to producing chemicals and materials in a sustainable and environmentally friendly manner. Despite its significance and widespread attention, various challenges persist in its industrial application. We propose a systematic approach to microbial biotechnology-a comprehensive framework for developing customized technologies tailored to the unique characteristics of the entire process for specific products. It utilizes approaches such as simplifying the process, sequential rearrangement, and coupling steps to systematically and holistically address the bottlenecks of the entire process in microbial manufacturing, aiming to achieve optimal economic and environmental benefits. This method involves the integration of multiple disciplines, including enzymology, synthetic biology, metabolic engineering, fermentation, separation engineering, and artificial intelligence (AI) technology. Here, we present several cases involving various stages of product bioproduction, developed under the concept of systematic microbial biotechnology, to demonstrate its effectiveness and advantages. The development and application of these technological concepts hold significant potential to shape the future of a sustainable circular bioeconomy driven by microbial manufacturing.

查看原文本刊更多论文

解决微生物制造中的挑战：系统微生物生物技术。

微生物制造提供了一种以可持续和环保的方式生产化学品和材料的替代方法。尽管其意义重大，受到广泛关注，但在工业应用中仍存在各种挑战。我们提出了一种系统的微生物生物技术方法——一种针对特定产品的整个过程的独特特征开发定制技术的综合框架。采用简化流程、顺序重排、耦合步骤等方法，系统、全面地解决微生物制造全过程中的瓶颈问题，以达到最优的经济效益和环境效益。这种方法涉及多学科的整合，包括酶学、合成生物学、代谢工程、发酵、分离工程和人工智能（AI）技术。在这里，我们提出了几个案例，涉及产品生物生产的各个阶段，在系统微生物生物技术的概念下发展，以证明其有效性和优势。这些技术概念的发展和应用具有巨大的潜力，可以塑造由微生物制造驱动的可持续循环生物经济的未来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

The Innovation MULTIDISCIPLINARY SCIENCES-

CiteScore

38.30

自引率

1.20%

发文量

134

审稿时长

6 weeks

期刊介绍： The Innovation is an interdisciplinary journal that aims to promote scientific application. It publishes cutting-edge research and high-quality reviews in various scientific disciplines, including physics, chemistry, materials, nanotechnology, biology, translational medicine, geoscience, and engineering. The journal adheres to the peer review and publishing standards of Cell Press journals. The Innovation is committed to serving scientists and the public. It aims to publish significant advances promptly and provides a transparent exchange platform. The journal also strives to efficiently promote the translation from scientific discovery to technological achievements and rapidly disseminate scientific findings worldwide. Indexed in the following databases, The Innovation has visibility in Scopus, Directory of Open Access Journals (DOAJ), Web of Science, Emerging Sources Citation Index (ESCI), PubMed Central, Compendex (previously Ei index), INSPEC, and CABI A&I.