Epidemiology, Risk Factors and Mortality of Fungal Bloodstream Infection: 14 Years of Experience at a Teaching Hospital.

IF 3.6 3区生物学 Q2 MYCOLOGY

Mycopathologia Pub Date : 2025-06-17 DOI:10.1007/s11046-025-00965-3

Júlia Pongrácz, Tamás Szabó, Emese Juhász, Miklós Iván, Katalin Kristóf

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引用次数: 0

Abstract

Fungal bloodstream infection is a severe condition associated with high mortality rates. Major risk factors of fungal bloodstream infection (BSI) include immunosuppression, abdominal surgery and malignancy. The epidemiology and underlying morbidities vary by geographic region and institute. We analyzed the species distribution, antifungal susceptibility, risk factors and mortality of fungal bloodstream infection at our institute over a 14-year period. Four-hundred and fourteen episodes were detected, and the average annual incidence was 0.23/1000 admissions. The most frequent species was Candida albicans (54%), followed by C. glabrata (16%). Abdominal surgery (48.3%), a solid tumor (31.4%), and immunosuppression (26.3%) were identified as major risk factors. Abdominal surgery was more prevalent in patients suffering from BSI caused by C. albicans or C. glabrata. C. tropicalis and C. albicans were associated with increased mortality in patients with neutropenia and/or immunosuppression. Azole prophylaxis in patients suffering from a hematologic malignancy or who recently had undergone organ transplantation increased the risk of C. krusei BSI. Overall 30-day mortality was 45.7% in any fungal BSI. Mortality of C. tropicalis BSI (59.4%) was the highest. Acquired antifungal resistance was not detected during the study period.

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真菌血流感染的流行病学、危险因素和死亡率：某教学医院14年的经验。

真菌血流感染是一种与高死亡率相关的严重疾病。真菌血流感染（BSI）的主要危险因素包括免疫抑制、腹部手术和恶性肿瘤。流行病学和潜在的发病率因地理区域和研究所而异。对我院14年来真菌血流感染的种类分布、药敏、危险因素及死亡率进行了分析。共发现414例，年平均发病率为0.23/1000。最常见的菌种为白色念珠菌（54%），其次为光滑念珠菌（16%）。腹部手术（48.3%）、实体瘤（31.4%）和免疫抑制（26.3%）被确定为主要危险因素。腹部手术在由白色念珠菌或光滑念珠菌引起的BSI患者中更为普遍。热带梭菌和白色梭菌与中性粒细胞减少和/或免疫抑制患者的死亡率增加有关。患有恶性血液病或最近接受过器官移植的患者使用唑预防会增加克鲁塞氏杆菌BSI的风险。真菌性BSI的30天总死亡率为45.7%。其中，热带棘球绦虫死亡率最高，为59.4%。在研究期间未检测到获得性抗真菌药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mycopathologia 生物-真菌学

CiteScore

6.80

自引率

3.60%

发文量

审稿时长

3 months

期刊介绍： Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.