[Secondary exposure to hormonal drugs].

Lakartidningen Pub Date : 2025-06-17
Karin Sjöström, James G Mount, Anna-Karin Klocker, Susanne Lindahl, Veronica Arthurson
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引用次数: 0

Abstract

Hormonal therapy is widely used to treat different conditions in humans; a well-known indication being the relief of menopausal symptoms in women. Transdermal delivery of hormonal drugs is common and may pose a risk to humans and animals through secondary exposure. This report raises awareness of risks associated with secondary exposure to transdermal hormone-containing drugs, based on evidence from spontaneous reporting of suspected adverse events. Clinical signs in humans included precocious puberty, unresolved virilisation, accelerated growth rate, alopecia, foetal death, and female infertility. In animals, clinical signs included persistent oestrus, poor growth rate and birth defects. Risks of secondary exposure must be acknowledged when prescribing hormonal drugs and as a possible aetiology of clinical signs in humans and animals.

[二次接触激素药物]。
激素疗法被广泛用于治疗人类的不同疾病;一个众所周知的迹象是缓解妇女的更年期症状。激素药物经皮传递是常见的,并可能通过二次接触对人类和动物构成风险。本报告基于疑似不良事件自发报告的证据,提高了人们对经皮含激素药物二次暴露相关风险的认识。人类的临床症状包括性早熟、未解决的男性化、生长速度加快、脱发、胎儿死亡和女性不育。在动物中,临床症状包括持续发情,生长缓慢和出生缺陷。在开具激素类药物处方时,必须承认二次暴露的风险,并将其作为人类和动物临床症状的可能病因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lakartidningen
Lakartidningen Medicine-Medicine (all)
CiteScore
0.30
自引率
0.00%
发文量
134
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