Development of Nanofiber Mats Impregnated With Ferula assa-foetida Essential Oil Nanogel for Antibacterial Wound Care.

IF 4.5 Q3 MATERIALS SCIENCE, BIOMATERIALS
International Journal of Biomaterials Pub Date : 2025-06-10 eCollection Date: 2025-01-01 DOI:10.1155/ijbm/1436095
Mahmoud Osanloo, Sahar Fereydonpour, Abbas Abdollahi, Mojdeh Safari
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引用次数: 0

Abstract

Bacterial infections pose significant threats to human health, and the rising issue of antibiotic resistance necessitates exploring alternative therapeutic strategies. In this study, Ferula assa-foetida essential oil (EO) as an herbal medicine was first analyzed using gas chromatography-mass spectrometry (GC-MS). Polycaprolactone-gelatin nanofibers were then prepared via electrospinning. Biological efficacies (antioxidant and antibacterial properties) of nanofibers impregnated with the nanogel containing the EO were finally investigated. As a result, the five major identified compounds were ethyl trifluoromethyl disulfide (33.6%), β-pinene (15.1%), δ-3-carene (6.6%), dihydro-β-agarofuran (6.0%), and γ-eudesmol (5.5%). Nanogel was developed from a primary nanoemulsion, with a 55 ± 7 nm droplet size and a zeta potential of -31 ± 2 mV. Nanofibers with a hydrophobic surface (contact angle (θ) 107°) impregnated with the nanogel demonstrated remarkable antibacterial efficacy, inhibiting the growth of Escherichia coli and Staphylococcus aureus by nearly 100% and Pseudomonas aeruginosa by 90%. These findings suggest that the developed formulation has the potential to serve as an effective antibacterial wound dressing, warranting further investigation.

伤口抗菌护理用阿魏精油纳米凝胶纳米纤维垫的研制。
细菌感染对人类健康构成重大威胁,抗生素耐药性问题日益严重,需要探索其他治疗策略。本研究首次采用气相色谱-质谱联用技术对中药阿魏精油进行了分析。采用静电纺丝法制备聚己内酯-明胶纳米纤维。最后研究了含EO纳米凝胶浸渍纳米纤维的生物性能(抗氧化和抗菌性能)。结果表明,鉴定出的5个主要化合物分别为三氟甲基二硫化乙酯(33.6%)、β-蒎烯(15.1%)、δ-3-蒈烯(6.6%)、二氢-β-琼脂呋喃(6.0%)和γ-桉树酚(5.5%)。纳米凝胶由初级纳米乳液制备而成,液滴尺寸为55±7 nm, zeta电位为-31±2 mV。纳米凝胶浸渍表面为疏水表面(接触角(θ) 107°)的纳米纤维具有显著的抗菌效果,对大肠杆菌和金黄色葡萄球菌的生长抑制率接近100%,对铜绿假单胞菌的生长抑制率为90%。这些发现表明,所开发的配方具有作为有效抗菌伤口敷料的潜力,值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Biomaterials
International Journal of Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
4.30
自引率
3.20%
发文量
50
审稿时长
21 weeks
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