Association of Visceral Adiposity with Nephropathy in Patients with Diabetes Mellitus: Data from Chinese and US Cohorts.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-06-12 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S516687

Fan Zhang, Wenjian Li

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Abstract

Purpose: This study examined the relationship between the visceral adiposity index (VAI) and diabetic nephropathy (DN) in patients with diabetes mellitus in two cohorts from China and the United States.

Patients and methods: After screening, 1,949 Chinese participants and 7,158 US participants were included in the analysis. Logistic regression models examined the relationship between VAI and DN. Concurrently, the restricted cubic spline (RCS) model was utilized to investigate the potential nonlinear relationship between VAI and DN. Additionally, segmented logistic regression analysis and subgroup analysis were conducted.

Results: In both cohorts, each unit increase in VAI was associated with a higher prevalence of DN, with a 4% increase (OR=1.04, P<0.001) observed in the Chinese cohort compared to a 3% rise (OR=1.03, P<0.001) in the US cohort. The RCS analysis revealed a nonlinear relationship between VAI and DN, with an inflection point identified at 5. The results of the subgroup analyses demonstrated that the positive correlation between VAI and DN was observed across diverse subgroups. However, the interaction between some subgroups indicated the presence of potential heterogeneity.

Conclusion: A significant positive association was observed between visceral adiposity and DN. Further research is required to elucidate the precise mechanisms by which visceral adiposity and DN are associated and to validate these findings in more diverse populations.

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糖尿病患者内脏脂肪与肾病的关系：来自中国和美国队列的数据

目的：研究中国和美国两组糖尿病患者的内脏脂肪指数（VAI）与糖尿病肾病（DN）之间的关系。患者和方法：筛选后，1949名中国参与者和7158名美国参与者被纳入分析。Logistic回归模型检验了VAI与DN之间的关系。同时，利用限制三次样条（RCS）模型研究了VAI与DN之间潜在的非线性关系。此外，还进行了分段logistic回归分析和亚组分析。结果：在两个队列中，VAI每增加一个单位都与DN患病率升高相关，增加4% （OR=1.04, p）。结论：内脏脂肪与DN之间存在显著的正相关。需要进一步的研究来阐明内脏肥胖和DN相关的确切机制，并在更多不同的人群中验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.