Association between Maternal Hypertension and Cleft Lip and Palate: A Mendelian Randomization Study.

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current medicinal chemistry Pub Date : 2025-06-13 DOI:10.2174/0109298673364806250523062350

Wenkang Luan, Shujun Fan, Haojun Liang, Dongwen Jiang, Leren He

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引用次数: 0

Abstract

Background: There is still no consensus on the etiology and risk factors of cleft lip and palate, and the causal relationship between maternal hypertension and cleft lip and palate remains uncertain.

Objective: We used two-sample Mendelian Randomization (MR) to investigate the causal effect of maternal hypertension on cleft lip and palate.

Methods: The MR study was performed using the statistics from the Genome-Wide Association Studies (GWAS) of maternal hypertension and cleft lip and palate. Using 25 Single-Nucleotide Polymorphisms (SNPs) robustly associated with maternal hypertension as instrumental variables, we employed several MR approaches, including Inverse Variance Weighted (IVW), weighted median, simple mode, MR-Egger, and weighted mode. Heterogeneity and pleiotropy tests were also conducted.

Results: The causal relationship between maternal hypertension and cleft lip and palate (CL/P) was identified using IVW (OR = 3.603, 95% CI = 1.184-10.964, p = 0.024). Additionally, a causal effect of maternal hypertension on cleft lip (CL) risk was identified using IVW (OR = 5.968, 95% CI = 1.023-34.819, p = 0.047). However, no significant association between maternal hypertension and Cleft Palate Only (CPO) was observed across all MR methods.

Conclusion: The MR analysis indicated that maternal hypertension is causally associated with the risk of CL/P and CL.

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产妇高血压与唇腭裂的关系：一项孟德尔随机研究。

背景：目前对唇腭裂的病因及危险因素尚无共识，产妇高血压与唇腭裂的因果关系尚不确定。目的：采用双样本孟德尔随机化（MR）方法探讨产妇高血压对唇腭裂的因果关系。方法：采用全基因组关联研究（GWAS）对产妇高血压和唇腭裂进行MR研究。使用25个与产妇高血压密切相关的单核苷酸多态性（snp）作为工具变量，我们采用了几种MR方法，包括逆方差加权（IVW）、加权中位数、简单模式、MR- egger和加权模式。异质性和多效性检验也进行了。结果：采用IVW方法确定产妇高血压与唇腭裂（CL/P）的因果关系（OR = 3.603, 95% CI = 1.184 ~ 10.964, P = 0.024）。此外，使用IVW确定产妇高血压对唇裂（CL）风险的因果影响（OR = 5.968, 95% CI = 1.023-34.819, p = 0.047）。然而，在所有MR方法中均未观察到产妇高血压与单纯腭裂（CPO）之间的显著关联。结论：MR分析提示产妇高血压与CL/P和CL的发生有因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.