Jia Liu, Madeline Cantu, Kyle O'Laughlin, David Cunningham, Akhil Mohan, Gail F Forrest, Steven Kirshblum, Kevin Kilgore, Anne Bryden, Svetlana Pundik, Tarun Arora, Gregory Nemunaitis, Francois Bethoux, Xiaofeng Wang, M Kristi Henzel, Ela B Plow
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引用次数: 0
Abstract
Objective: Understanding motor neurophysiology is important for developing effective upper limb treatments for people with tetraplegia following cervical spinal cord injury (SCI). While literature has primarily focused on contralateral motor pathways, neurophysiology of ipsilateral pathways remains largely unexplored in tetraplegia. We aimed to investigate ipsilateral physiology and its relationship to upper limb function in individuals with tetraplegia.
Methods: Twenty-three individuals with tetraplegia and 24 age-matched controls underwent transcranial magnetic stimulation to assess ipsilateral and contralateral motor physiology in the biceps muscle of the weaker arm. We also evaluated upper limb function and spasticity in tetraplegia.
Results: There were no differences in ipsilateral motor evoked potential (iMEP) features (amplitudes, onsets, offsets, durations, and areas) between participants with tetraplegia and controls (all p > 0.05). However, participants with tetraplegia who had larger iMEP amplitudes also had larger contralateral MEP amplitudes (p = 0.008) and better proximal arm motor function (p = 0.031).
Conclusion: Ipsilateral motor physiology is associated with contralateral physiology and proximal arm motor function in tetraplegia.
Significance: Ipsilateral pathways may play a role in proximal arm function in tetraplegia. However, injury-specific adaptations were missed due to preserved biceps strength in our sample. Future studies should investigate iMEPs in non-preserved muscles to establish injury-specific relevance for rehabilitation.
期刊介绍：
As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology.
Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.
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