Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea Treatment.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-06-12 eCollection Date: 2025-01-01 DOI:10.2147/CCID.S525787

Maogen Ye, Pingsheng Hao, Nana Luo, Tianhao Li

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Abstract

Rosacea is a common dermatological disease, and the complexity of its etiology and pathogenesis makes conventional treatment of rosacea difficult. Small-molecule drugs are a new option for the treatment of rosacea. Based on its good efficacy, convenience of use, affordable price and other advantages, more and more small-molecule drugs are used in the treatment and management of rosacea, involving a variety of molecular pathways, including JAK/STAT signaling pathway, TRPV, TLR2-KLK5-LL37 and mTOR pathways, Th1/Th17-IL17, PED-4, AhR and MRGPRX2. However, the specific treatment mechanism and research progress have not been systematically elucidated. This review summarizes the latest advances in small molecules targeting key inflammatory pathways in rosacea, provides new ideas for the treatment of rosacea and new directions for the clinical management of rosacea. In addition, we need to pay attention to individual differences in patients, the side effects of drugs and formulations. Therefore, further research on small-molecule drugs for the treatment of rosacea is very necessary.

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小分子疗法治疗酒渣鼻的机制及最新进展。

酒渣鼻是一种常见的皮肤病，其病因和发病机制的复杂性使酒渣鼻的常规治疗变得困难。小分子药物是治疗酒渣鼻的新选择。基于其疗效好、使用方便、价格实惠等优势，越来越多的小分子药物被用于酒痤疮的治疗和管理，涉及多种分子通路，包括JAK/STAT信号通路、TRPV、TLR2-KLK5-LL37和mTOR通路、Th1/Th17-IL17、PED-4、AhR和MRGPRX2。然而，具体的治疗机制和研究进展尚未系统阐明。本文综述了小分子靶向酒渣鼻关键炎症通路的最新进展，为酒渣鼻的治疗提供新思路，为酒渣鼻的临床治疗提供新方向。此外，我们需要注意患者的个体差异，药物和配方的副作用。因此，进一步研究小分子药物治疗酒渣鼻是非常必要的。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.