Impact of Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 supplementation on the gut microbiota and metabolic health of alcohol-consuming individuals: a randomised, double-blind, placebo-controlled trial.

IF 3 4区医学 Q2 MICROBIOLOGY

Beneficial microbes Pub Date : 2025-06-16 DOI:10.1163/18762891-bja00083

Y Liu, J Wang, Y Gao, Z Wang, C Zhu, F Xu, Y Chen

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引用次数: 0

Abstract

Aim: this study explored the impact of BLa80 (Bifidobacterium animalis subsp. lactis) and LRa05 (Lacticaseibacillus rhamnosus) on the gut microbiota composition and metabolic indicators of volunteers with alcohol-consuming habits.

Methods: in this randomised, placebo-controlled trial, we assessed the impacts of a probiotic complex containing BLa80 and LRa05 (BLC) on the gut microbiota, short-chain fatty acids (SCFAs), alanine transaminase (ALT), aspartate aminotransferase (AST) and uric acid levels in healthy participants. A total of 112 subjects were randomly assigned to receive either a placebo (maltodextrin) or the intervention (maltodextrin + BLC at 20 billion colony-forming units/day) for eight weeks. Gut microbiota alterations were monitored via 16S rRNA gene sequencing, while fecal SCFAs were quantified via gas chromatography-mass spectrometry (GC-MS). Key metabolic indicators, including ALT, AST, and uric acid, were also measured.

Results: BLC intervention maintained the gut microbiota composition in participants with alcohol consumption habits, notably increasing the abundance of beneficial genera such as Blautia, Faecalibacterium, and Subdoligranulum. Significant alterations were observed in the levels of acetic acid, valeric acid, and total SCFAs, suggesting a favourable influence on gut health and metabolic function. Furthermore, BLC showed potential for improving serum uric acid levels.

Conclusion: supplementation with BLC appears to beneficially modulate the composition of the gut microbiota, aiding in the management of alcohol-related gastrointestinal disturbances and dependency. These findings highlight BLC's potential as a therapeutic adjunct for alcohol-induced gut dysbiosis, offering a non-pharmacological strategy to mitigate metabolic risks and improve gut barrier integrity in individuals with chronic alcohol consumption. This intervention may significantly contribute to gut health improvement.

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动物双歧杆菌亚种的影响。补充乳酸杆菌BLa80和鼠李糖乳酸杆菌LRa05对饮酒个体肠道微生物群和代谢健康的影响：一项随机、双盲、安慰剂对照试验

目的：探讨动物双歧杆菌BLa80 (Bifidobacterium animalis subsp。LRa05（鼠李糖乳杆菌）对饮酒习惯志愿者肠道菌群组成和代谢指标的影响。方法：在这项随机、安慰剂对照试验中，我们评估了含有BLa80和LRa05 （BLC）的益生菌复合物对健康参与者肠道微生物群、短链脂肪酸（SCFAs）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和尿酸水平的影响。总共112名受试者被随机分配接受安慰剂（麦芽糖糊精）或干预（麦芽糖糊精+ BLC， 200亿菌落形成单位/天），为期8周。通过16S rRNA基因测序监测肠道微生物群的变化，而通过气相色谱-质谱（GC-MS）定量粪便scfa。同时测定ALT、AST、尿酸等关键代谢指标。结果：BLC干预维持了有饮酒习惯的参与者的肠道微生物群组成，显著增加了Blautia、Faecalibacterium和Subdoligranulum等有益菌的丰度。在乙酸、戊酸和总短链脂肪酸水平上观察到显著的改变，表明对肠道健康和代谢功能有有利的影响。此外，BLC显示出改善血清尿酸水平的潜力。结论：补充BLC似乎有利于调节肠道微生物群的组成，有助于管理与酒精相关的胃肠道紊乱和依赖。这些发现强调了BLC作为酒精性肠道生态失调治疗辅助药物的潜力，提供了一种非药物策略来减轻慢性饮酒个体的代谢风险和改善肠道屏障完整性。这种干预可能显著有助于肠道健康的改善。

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来源期刊

Beneficial microbes MICROBIOLOGY-NUTRITION & DIETETICS

CiteScore

7.90

自引率

1.90%

发文量

审稿时长

>12 weeks

期刊介绍： Beneficial Microbes is a peer-reviewed scientific journal with a specific area of focus: the promotion of the science of microbes beneficial to the health and wellbeing of man and animal. The journal contains original research papers and critical reviews in all areas dealing with beneficial microbes in both the small and large intestine, together with opinions, a calendar of forthcoming beneficial microbes-related events and book reviews. The journal takes a multidisciplinary approach and focuses on a broad spectrum of issues, including safety aspects of pro- & prebiotics, regulatory aspects, mechanisms of action, health benefits for the host, optimal production processes, screening methods, (meta)genomics, proteomics and metabolomics, host and bacterial physiology, application, and role in health and disease in man and animal. Beneficial Microbes is intended to serve the needs of researchers and professionals from the scientific community and industry, as well as those of policy makers and regulators. The journal will have five major sections: * Food, nutrition and health * Animal nutrition * Processing and application * Regulatory & safety aspects * Medical & health applications In these sections, topics dealt with by Beneficial Microbes include: * Worldwide safety and regulatory issues * Human and animal nutrition and health effects * Latest discoveries in mechanistic studies and screening methods to unravel mode of action * Host physiology related to allergy, inflammation, obesity, etc. * Trends in application of (meta)genomics, proteomics and metabolomics * New developments in how processing optimizes pro- & prebiotics for application * Bacterial physiology related to health benefits