The association between dietary live microbes intake and PhenoAge in US non-diabetes adults and the mediating effect of insulin resistance: NHANES 2007-2018.

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2025-06-17 DOI:10.1007/s40520-025-03104-6

Yuhan Yang, Ziyi Sun, Jianguo Lin, Qingqing Wang, Xiaoning Sun, Tong Tong, Xiaoxiao Zhang, Cheng Li, Kuiwu Yao

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引用次数: 0

Abstract

Background/objectives: Diets enriched with live microbes offer multiple health benefits. This study aimed to investigate the relationship between dietary intake of live microbes and accelerated biological age, as well as to examine the mediating role of insulin resistance.

Methods: The study included 4,909 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2018. Dietary live microbes intake was assessed using a self-report questionnaire. Insulin resistance was measured using the HOMA-IR and plasma insulin levels. Biological age and accelerated aging were assessed using PhenoAge and PhenoAgeAccel. We performed weighted multiple linear regression, logistic regression, restricted cubic spline (RCS) analysis, mediation analyses, and interaction analyses to explore the relationships between dietary live microbe intake, insulin resistance, and accelerated aging.

Results: Higher intake of live dietary microbes, compared to lower intake, was associated with a slower rate of accelerated aging after full adjustment for confounders (β = 0.15; 95% CI: - 0.26 to - 0.04; P = 0.008). RCS curves indicated an L-shaped dose-response relationship (P-nonlinear = 0.0003). Insulin resistance-related metrics (HOMA-IR and insulin) partially mediated these effects, with mediation proportions ranging from 24.65% to 30.03%. Interaction analyses revealed no significant interaction between dietary live microbe intake and other stratification factors regarding phenotypic age.

Conclusions: The intake of dietary live microbes is nonlinearly associated with accelerated biological age. IR partially mediated the relationship.

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美国非糖尿病成年人饮食活微生物摄入量与表型之间的关系以及胰岛素抵抗的中介作用：NHANES 2007-2018。

背景/目的：富含活微生物的饮食对健康有多种益处。本研究旨在探讨饮食中活微生物摄入与生物年龄加速的关系，并探讨胰岛素抵抗在其中的中介作用。方法：该研究纳入了2007年至2018年间进行的国家健康与营养检查调查（NHANES）的4909名参与者。采用自我报告问卷评估饮食中活微生物的摄入量。采用HOMA-IR和血浆胰岛素水平测量胰岛素抵抗。使用PhenoAge和PhenoAgeAccel评估生物年龄和加速衰老。我们通过加权多元线性回归、逻辑回归、限制三次样条（RCS）分析、中介分析和交互分析来探讨饮食中活微生物摄入、胰岛素抵抗和加速衰老之间的关系。结果：在完全调整混杂因素后，较高的活微生物摄入量与较低的摄入量相比，与较慢的加速衰老率相关(β = 0.15；95% CI: - 0.26 ~ - 0.04；p = 0.008)。RCS曲线呈l型剂量-响应关系（p -非线性= 0.0003）。胰岛素抵抗相关指标（HOMA-IR和胰岛素）部分介导了这些影响，中介比例从24.65%到30.03%不等。交互作用分析显示，饮食中活微生物摄入量与其他有关表型年龄的分层因素之间无显著交互作用。结论：饲粮中活菌的摄入与生物年龄的加速呈非线性相关。IR部分介导了这一关系。

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来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.