Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy

IF 3.7 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Pub Date : 2025-06-19 DOI:10.1111/1753-0407.70116

Qian Lei, Burton B. Yang, Juanjuan Lyu

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Abstract

Background

Diabetes represents a significant global health concern, with diabetic cardiomyopathy (DCM) emerging as a primary cause of mortality among individuals with diabetes. Despite the prevalence of DCM, advancements in therapeutic and preventative strategies remain constrained.

Methods

Recent studies were reviewed to provide a comprehensive summary of pathogenesis and clinical treatment of DCM, effect of ferroptosis, and potential value of ferroptosis inhibitors in DCM intervention.

Results

A growing body of research indicates that oxidative stress, inflammatory reactions, and other factors play a role in the onset and progression of DCM. Oxidative stress within cardiomyocytes is a primary mechanism implicated in the development of DCM, whereby heightened intracellular reactive oxygen species (ROS) facilitate cell death via ferroptosis. Ferroptosis inhibitors hold great promise as therapeutic agents.

Conclusions

This review provides an overview of the involvement of iron homeostasis regulation, oxidative stress, and ferroptosis in DCM, and the significance of ferroptosis in the prevention and treatment of DCM.

Abstract Image

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针对上睑下垂对糖尿病性心肌病干预的潜在意义

糖尿病是一个重要的全球健康问题，糖尿病性心肌病（DCM）已成为糖尿病患者死亡的主要原因。尽管DCM普遍存在，但治疗和预防策略的进展仍然受到限制。方法对近年来有关DCM的发病机制、临床治疗、铁下垂的作用及铁下垂抑制剂在DCM干预中的潜在价值进行综述。结果越来越多的研究表明，氧化应激、炎症反应等因素在DCM的发生和发展中起作用。心肌细胞内的氧化应激是DCM发生的主要机制，细胞内活性氧（ROS）的升高通过铁凋亡促进细胞死亡。下垂铁抑制剂作为治疗药物具有很大的前景。本文综述了铁稳态调节、氧化应激和铁下垂在DCM中的作用，以及铁下垂在DCM预防和治疗中的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.