Association Between Handgrip Strength and Suicidal Ideation: A Systematic Review and Meta-Analysis

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-06-18 DOI:10.1002/brb3.70647

Prakasini Satapathy, Abhay M Gaidhane, Nasir Vadia, Soumya V Menon, Kattela Chennakesavulu, Rajashree Panigrahi, Manpreet Kaur, Ganesh Bushi, Muhammed Shabil, Diptismita Jena, Mayank Goyal, Harish Kumar, Anju Rani, Sanjit Sah, Khang Wen Goh

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Abstract

Background

Suicidal ideation is a global public health concern, highlighting the need to identify modifiable risk factors. Handgrip strength (HGS), an objective measure of muscular strength, has been linked to mental health outcomes. This review synthesizes evidence on HGS and suicidal ideation, exploring modifiers such as sex.

Methods

This systematic review and meta-analysis, registered with PROSPERO and conducted in accordance with PRISMA guidelines, evaluated data retrieved from PubMed, Embase, and Web of Science up to November 30, 2024. The analysis focused on randomized controlled trials and observational studies—including case-control, cohort, and cross-sectional designs—that examined the relationship between HGS and suicidal ideation in human populations. A random-effects model was employed to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs). Heterogeneity among studies was assessed using the I² statistic.

Results

Out of 294 studies, 9 met the inclusion criteria for the systematic review, and 6 were eligible for meta-analysis, involving 81,035 participants. The pooled analysis showed a nonsignificant association between HGS and suicidal ideation. For males, the pooled OR per 1 kg increase in HGS was 0.939 (95% CI, 0.875–1.009), and for females, it was 0.851 (95% CI, 0.662–1.094), indicating a potential but nonsignificant protective effect.

Conclusion

This systematic review and meta-analysis found no statistically significant association between handgrip strength and suicidal ideation in the pooled analysis. However, consistent trends observed in the qualitative synthesis suggest a potential relationship that warrants further investigation. Longitudinal studies are essential to elucidate the underlying mechanisms.

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握力与自杀意念的关系：系统回顾与元分析

自杀意念是一个全球性的公共卫生问题，因此需要确定可改变的风险因素。握力（HGS）是衡量肌肉力量的一种客观指标，与心理健康状况有关。这篇综述综合了HGS和自杀意念的证据，探讨了性别等修饰因素。该系统综述和荟萃分析在PROSPERO注册，按照PRISMA指南进行，评估了截至2024年11月30日从PubMed、Embase和Web of Science检索的数据。分析集中于随机对照试验和观察性研究——包括病例对照、队列和横断面设计——这些研究检验了HGS和人群自杀意念之间的关系。采用随机效应模型计算95%置信区间（ci）的合并优势比（ORs）。采用I2统计量评估研究间的异质性。结果294项研究中，9项符合系统评价的纳入标准，6项符合荟萃分析的标准，涉及81,035名参与者。合并分析显示HGS与自杀意念之间无显著关联。对于男性，每增加1 kg HGS的综合OR为0.939 (95% CI, 0.875-1.009)，对于女性，OR为0.851 (95% CI, 0.662-1.094)，表明可能存在但不显著的保护作用。结论本系统综述和荟萃分析在汇总分析中没有发现握力与自杀意念有统计学意义的关联。然而，在定性综合中观察到的一致趋势表明，一种潜在的关系值得进一步调查。纵向研究对于阐明潜在的机制至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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