Bilayer target for efficient production of 47Sc from proton-induced irradiation

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-06-14 DOI:10.1016/j.apradiso.2025.111957

Luciano Canton , Francesca Barbaro , Yuliia Lashko , Lucia De Dominicis , Liliana Mou , Gaia Pupillo

引用次数: 0

Abstract

The production of ⁴⁷Sc for nuclear medicine applications is a complex challenge requiring innovative approaches to enhance yield and purity. In this study, we introduce a bilayer-target strategy using natural vanadium (

^{nat}

V) and enriched ⁵⁰Ti irradiated by intermediate-energy proton beams. This novel methodology significantly advances the field, offering improved production efficiency without compromising radionuclidic purity, crucial for theranostic applications in precision medicine.

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质子诱导辐照高效产生47Sc的双层靶

生产用于核医学的47Sc是一项复杂的挑战，需要创新的方法来提高产量和纯度。在这项研究中，我们介绍了一种利用天然钒（natV）和富50Ti在中能质子束照射下的双层靶策略。这种新颖的方法显著推进了该领域的发展，在不影响放射性核素纯度的情况下提高了生产效率，这对精准医学的治疗应用至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.