Host-like conditions validate nutrient transport as an antimalarial drug target

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2025-06-19 DOI:10.1016/j.chembiol.2025.05.006

Rodion Gordzevich , Eric D. Brown

引用次数: 0

Abstract

Antimalarial drug discovery largely relies on nutrient-rich media that may obscure physiologically relevant targets. In this issue of Cell Chemical Biology, Molina et al.¹ validate the plasmodial surface anion channel as essential for Plasmodium falciparum survival under nutrient-restricted conditions, demonstrating how physiological media can expose druggable biology overlooked by standard screening approaches.

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类宿主条件验证了营养转运作为抗疟疾药物靶点的有效性

抗疟药物的发现很大程度上依赖于富含营养的培养基，这可能会掩盖生理上相关的靶标。在这一期的《细胞化学生物学》中，Molina等人1证实了疟原虫表面阴离子通道是恶性疟原虫在营养受限条件下存活的必要条件，证明了生理介质如何暴露被标准筛选方法忽视的可药物生物学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.