A qualitative study exploring the barriers and facilitators of conducting the SARS-CoV2 Immunity & Reinfection Evaluation (SIREN) study during the COVID-19 pandemic: Implications for developing resilient NHS research structures

IF 3.9 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Public Health Pub Date : 2025-06-18 DOI:10.1016/j.puhe.2025.105818

Atiya Kamal , Jack Haywood , Dominic Sparkes , Anna Howells , Sophie Russell , Susan Hopkins , Jasmin Islam , Victoria Hall

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引用次数: 0

Abstract

Objectives

The SARS-CoV-2 Immunity and Reinfection Evaluation (SIREN) study is a prospective multicentre cohort study established to evaluate the immune response to SARS-CoV-2 following infection and vaccination in UK healthcare workers. The aim of this study is to explore barriers and facilitators experienced by SIREN sites to set-up and run the study, and implications for future research within NHS systems.

Study design

Qualitative study.

Methods

Seven focus groups (n = 33) and three one-to-one semi-structured interviews (n = 3) were conducted via MS Teams with SIREN site teams and SIREN participants.

Results

A thematic analysis indicates a decentralised model, multidisciplinary team working, pre-existing networks, visible senior support, diverse recruitment methods, and co-design methods contributed to the success of SIREN. Barriers to setting up SIREN sites included limited experience of running a large-scale study, lack of processes and resources, and limited organisational support. Providing SIREN sites with the flexibility to develop models of practice that consider the local context worked well. More centralised support including documents, templates and provision for peer support and shared learning can lower the administrative burden of local site teams.

Conclusions

Participation in the SIREN study has strengthened the research infrastructure of local sites and promoted more collaborative research processes which should be maintained to address future challenges at pace within NHS systems.

查看原文本刊更多论文

一项探讨在COVID-19大流行期间进行SARS-CoV2免疫和再感染评估（SIREN）研究的障碍和促进因素的定性研究：对建立弹性NHS研究结构的影响

目的：SARS-CoV-2免疫和再感染评估（SIREN）研究是一项前瞻性多中心队列研究，旨在评估英国医护人员感染和接种SARS-CoV-2后的免疫反应。本研究的目的是探索SIREN站点设置和运行研究时遇到的障碍和促进因素，以及对NHS系统内未来研究的影响。研究设计定性研究。方法通过MS Teams与SIREN现场团队和SIREN参与者进行7个焦点小组（n = 33）和3个一对一半结构化访谈（n = 3）。结果专题分析表明，分散的模式、多学科团队合作、已有的网络、可见的高层支持、多样化的招聘方法和协同设计方法是SIREN成功的因素。建立SIREN站点的障碍包括运行大规模研究的经验有限，缺乏流程和资源，以及有限的组织支持。为SIREN站点提供灵活性来开发考虑当地情况的实践模型，效果很好。更集中的支持，包括文档、模板和提供同伴支持和共享学习，可以降低本地站点团队的管理负担。结论参与SIREN研究加强了当地站点的研究基础设施，促进了更多的合作研究过程，这些研究过程应该保持下去，以应对NHS系统内未来的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.