Flush with insight: Decoding GPCR crosstalk in the spinal defecation center

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2025-06-19 DOI:10.1016/j.chembiol.2025.05.011

Nil Casajuana-Martin , Eli F. McDonald , M. Madan Babu

引用次数: 0

Abstract

G protein-coupled receptors (GPCRs) are increasingly recognized as part of interconnected, cell-context-specific signaling networks. In the June 5^th issue of Molecular Cell, Dehkhoda et al.¹ demonstrate that the constitutive activity of the ghrelin receptor drives dopamine D2 receptor-dependent calcium mobilization, highlighting the complexity of GPCR signaling and opening new avenues for therapeutic development.

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顿悟：解码脊髓排便中心的GPCR串音

G蛋白偶联受体（gpcr）越来越被认为是相互关联的细胞上下文特异性信号网络的一部分。在6月5日出版的Molecular Cell杂志上，Dehkhoda等人1证明了ghrelin受体的组成活性驱动多巴胺D2受体依赖性钙动员，突出了GPCR信号传导的复杂性，并为治疗开发开辟了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.