Research progress of lipid metabolism reprogramming and related drug therapy in ovarian cancer

Abstract

Ovarian cancer is the most malignant gynecological tumor. Dysregulation of lipid metabolism is not only associated with the formation of tumor cells, but also plays an important role in the invasion and drug resistance of ovarian cancer. Dysregulation of lipid metabolism involves multiple aspects such as lipid uptake, storage, excretion, and fatty acids oxidation. Dysregulation of lipid metabolism affects tumor proliferation, migration, and drug resistance formation by generating more energy and synthesizing new lipid metabolites or activating related signaling pathways, leading to poor prognosis. This article reviews the role of fatty acid metabolism in ovarian cancer and the research progress in the field of drug therapy, suggesting that fatty acid and related lipid metabolism pathways are potential therapeutic targets for ovarian cancer.